Cytochrome P450 for Citreohybridonol Synthesis : Oxidative Derivatization of the Andrastin Scaffold

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)296-299
Journal / PublicationOrganic Letters
Volume18
Issue number2
Online published5 Jan 2016
Publication statusPublished - 15 Jan 2016
Externally publishedYes

Abstract

A biosynthetic gene cluster similar to that for andrastin A (1) was discovered in Emericella variecolor NBRC 32302. Ctr-P450, a cytochrome P450 uniquely present in the cluster, was coexpressed with the andrastin A biosynthetic genes, leading to the production of the antifeedant agent citreohybridonol (4), along with four new andrastin derivatives. The results revealed the unusual multifunctionality of Ctr-P450 and indicated that this approach can be applied for further natural product diversification.

Citation Format(s)

Cytochrome P450 for Citreohybridonol Synthesis : Oxidative Derivatization of the Andrastin Scaffold. / Matsuda, Yudai; Quan, Zhiyang; Mitsuhashi, Takaaki; Li, Chang; Abe, Ikuro.

In: Organic Letters, Vol. 18, No. 2, 15.01.2016, p. 296-299.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal