Cu2-xSe@mSiO2-PEG core-shell nanoparticles: A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

Xijian Liu; Qian Wang; Chun Li; Rujia Zou; Bo Li; Guosheng Song; Kaibing Xu; Yun Zheng; Junqing Hu

doi:10.1039/c3nr06160d

Cu_2-xSe@mSiO₂-PEG core-shell nanoparticles: A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

Xijian Liu
, Qian Wang
, Chun Li
, Rujia Zou
, Bo Li
, Guosheng Song
, Kaibing Xu
, Yun Zheng
, Junqing Hu

Centre of Super-Diamond and Advanced Films

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

82 Citations (Scopus)

Abstract

A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cu_2-xSe@mSiO ₂-PEG core-shell nanoparticles is reported. Silica coating and further PEG modification improve the hydrophilicity and biocompatibility of copper selenide nanoparticles. As-prepared Cu_2-xSe@mSiO ₂-PEG nanoparticles not only display strong near infrared (NIR) region absorption and good photothermal effect, but also exhibit excellent biocompatibility. The mesoporous silica shell is provided as the carrier for loading the anticancer drug, doxorubicin (DOX). Moreover, the release of DOX from Cu_2-xSe@mSiO₂-PEG core-shell nanoparticles can be triggered by pH and NIR light, resulting in a synergistic effect for killing cancer cells. Importantly, the combination of photothermal therapy and chemotherapy driven by NIR radiation with safe power density significantly improves the therapeutic efficacy, and demonstrates better therapeutic effects for cancer treatment than individual therapy. © the Partner Organisations 2014.

Original language	English
Pages (from-to)	4361-4370
Journal	Nanoscale
Volume	6
Issue number	8
DOIs	https://doi.org/10.1039/c3nr06160d
Publication status	Published - 21 Apr 2014

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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Cite this

@article{55f1896e1e1842268187e1674dec90f4,

title = "Cu2-xSe@mSiO2-PEG core-shell nanoparticles: A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density",

abstract = "A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cu2-xSe@mSiO 2-PEG core-shell nanoparticles is reported. Silica coating and further PEG modification improve the hydrophilicity and biocompatibility of copper selenide nanoparticles. As-prepared Cu2-xSe@mSiO 2-PEG nanoparticles not only display strong near infrared (NIR) region absorption and good photothermal effect, but also exhibit excellent biocompatibility. The mesoporous silica shell is provided as the carrier for loading the anticancer drug, doxorubicin (DOX). Moreover, the release of DOX from Cu2-xSe@mSiO2-PEG core-shell nanoparticles can be triggered by pH and NIR light, resulting in a synergistic effect for killing cancer cells. Importantly, the combination of photothermal therapy and chemotherapy driven by NIR radiation with safe power density significantly improves the therapeutic efficacy, and demonstrates better therapeutic effects for cancer treatment than individual therapy. {\textcopyright} the Partner Organisations 2014.",

author = "Xijian Liu and Qian Wang and Chun Li and Rujia Zou and Bo Li and Guosheng Song and Kaibing Xu and Yun Zheng and Junqing Hu",

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Cu_2-xSe@mSiO₂-PEG core-shell nanoparticles: A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density. / Liu, Xijian; Wang, Qian; Li, Chun et al.
In: Nanoscale, Vol. 6, No. 8, 21.04.2014, p. 4361-4370.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Cu2-xSe@mSiO2-PEG core-shell nanoparticles

T2 - A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

AU - Liu, Xijian

AU - Wang, Qian

AU - Li, Chun

AU - Zou, Rujia

AU - Li, Bo

AU - Song, Guosheng

AU - Xu, Kaibing

AU - Zheng, Yun

AU - Hu, Junqing

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2014/4/21

Y1 - 2014/4/21

N2 - A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cu2-xSe@mSiO 2-PEG core-shell nanoparticles is reported. Silica coating and further PEG modification improve the hydrophilicity and biocompatibility of copper selenide nanoparticles. As-prepared Cu2-xSe@mSiO 2-PEG nanoparticles not only display strong near infrared (NIR) region absorption and good photothermal effect, but also exhibit excellent biocompatibility. The mesoporous silica shell is provided as the carrier for loading the anticancer drug, doxorubicin (DOX). Moreover, the release of DOX from Cu2-xSe@mSiO2-PEG core-shell nanoparticles can be triggered by pH and NIR light, resulting in a synergistic effect for killing cancer cells. Importantly, the combination of photothermal therapy and chemotherapy driven by NIR radiation with safe power density significantly improves the therapeutic efficacy, and demonstrates better therapeutic effects for cancer treatment than individual therapy. © the Partner Organisations 2014.

AB - A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cu2-xSe@mSiO 2-PEG core-shell nanoparticles is reported. Silica coating and further PEG modification improve the hydrophilicity and biocompatibility of copper selenide nanoparticles. As-prepared Cu2-xSe@mSiO 2-PEG nanoparticles not only display strong near infrared (NIR) region absorption and good photothermal effect, but also exhibit excellent biocompatibility. The mesoporous silica shell is provided as the carrier for loading the anticancer drug, doxorubicin (DOX). Moreover, the release of DOX from Cu2-xSe@mSiO2-PEG core-shell nanoparticles can be triggered by pH and NIR light, resulting in a synergistic effect for killing cancer cells. Importantly, the combination of photothermal therapy and chemotherapy driven by NIR radiation with safe power density significantly improves the therapeutic efficacy, and demonstrates better therapeutic effects for cancer treatment than individual therapy. © the Partner Organisations 2014.

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M3 - RGC 21 - Publication in refereed journal

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SN - 2040-3364

VL - 6

SP - 4361

EP - 4370

JO - Nanoscale

JF - Nanoscale

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