Curcumin inhibits classical swine fever virus replication by interfering with lipid metabolism

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Ya Gao
  • Jia-Huan Hu
  • Xiao-Dong Liang
  • Jing Chen
  • Chun-Chun Liu
  • Ya-Yun Liu
  • Yan Cheng
  • Bin Zhou

Detail(s)

Original languageEnglish
Article number109152
Journal / PublicationVeterinary Microbiology
Volume259
Online published12 Jun 2021
Publication statusPublished - Aug 2021

Abstract

Although previous reports have shown that Curcumin inhibits many viruses, including some important members of different genera of Flaviviridae family (Japanese encephalitis virus, dengue virus and hepatitis C virus), the antiviral activity of curcumin against Classical swine fever virus (CSFV), which belongs to Pestivirus genus, is still unclear. In this study, we found that curcumin inhibited CSFV replication in a dose-dependent manner, but had no effect on virus adsorption and entry. Furthermore, the results showed that curcumin inhibited the expression of FASN, one of the key enzymes of fatty acid synthesis pathway, thereby, causing the reduction of the production of LDs upon infection. To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression. Therefore, it is confirmed that curcumin inhibited CSFV replication by interfere lipid metabolism. In addition, our subsequent studies found that curcumin played an antiviral role by promoting the innate immune independent of NF-κB signaling pathway. Taken together, our finding highlights that curcumin is a potential candidate drug against CSFV for controlling CSF.

Research Area(s)

  • Antiviral activity, Classical swine fever virus (CSFV), Curcumin, Innate immunity, Lipid metabolism

Citation Format(s)

Curcumin inhibits classical swine fever virus replication by interfering with lipid metabolism. / Gao, Ya; Hu, Jia-Huan; Liang, Xiao-Dong; Chen, Jing; Liu, Chun-Chun; Liu, Ya-Yun; Cheng, Yan; Go, Yun Young; Zhou, Bin.

In: Veterinary Microbiology, Vol. 259, 109152, 08.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review