TY - JOUR
T1 - Curcumin-Encapsulated Co-ZIF-8 for Ulcerative Colitis Therapy
T2 - ROS Scavenging and Macrophage Modulation Effects
AU - Tao, Qi
AU - Yao, Hang
AU - Wang, Feifei
AU - Gu, Zehao
AU - Yang, Xiaofei
AU - Zhao, Yuchi
AU - Pang, Huan
AU - Wang, Dong-An
AU - Chong, Hui
PY - 2024/7/16
Y1 - 2024/7/16
N2 - Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by the disruption of the intestinal epithelial barrier. This study described the synthesis and characterization of CCM-Co-ZIF-8, a novel composite material with enzyme-like activities similar to catalase, peroxidase, and superoxide dismutase. CCM-Co-ZIF-8 demonstrated the ability to scavenge reactive oxygen species that play a critical role in UC pathogenesis. In vitro studies using lipopolysaccharide-induced RAW264.7 cells showed that CCM-Co-ZIF-8 exhibited anti-inflammatory activity by promoting the transition of macrophages from an M1 to an M2 phenotype. In vivo experiments using a mouse model of UC demonstrated that CCM-Co-ZIF-8 suppressed the expression of proinflammatory cytokines. These findings suggested that CCM-Co-ZIF-8 might hold promise as a therapeutic strategy for the treatment of UC. © 2024 The Authors. Published by American Chemical Society.
AB - Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by the disruption of the intestinal epithelial barrier. This study described the synthesis and characterization of CCM-Co-ZIF-8, a novel composite material with enzyme-like activities similar to catalase, peroxidase, and superoxide dismutase. CCM-Co-ZIF-8 demonstrated the ability to scavenge reactive oxygen species that play a critical role in UC pathogenesis. In vitro studies using lipopolysaccharide-induced RAW264.7 cells showed that CCM-Co-ZIF-8 exhibited anti-inflammatory activity by promoting the transition of macrophages from an M1 to an M2 phenotype. In vivo experiments using a mouse model of UC demonstrated that CCM-Co-ZIF-8 suppressed the expression of proinflammatory cytokines. These findings suggested that CCM-Co-ZIF-8 might hold promise as a therapeutic strategy for the treatment of UC. © 2024 The Authors. Published by American Chemical Society.
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U2 - 10.1021/acsomega.4c02446
DO - 10.1021/acsomega.4c02446
M3 - RGC 21 - Publication in refereed journal
C2 - 39035970
SN - 2470-1343
VL - 9
SP - 30571
EP - 30582
JO - ACS Omega
JF - ACS Omega
IS - 28
ER -