Crystallization and microstructure analysis of calcium phosphate-based glass ceramics for biomedical applications

Yong Zhang, J. D. Santos

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

71 Citations (Scopus)

Abstract

Calcium phosphate glasses and glass ceramics (CaO/P2O5 = 1.25 in molar ratio) modified by small amounts of additives such as Na2O, MgO, TiO2 and ZrO2 were prepared after appropriate heat treatment for nucleation and crystallization. Based upon differential thermal analysis (DTA) results, a two-step heat treatment was used for crystal nucleation and growth. X-ray diffraction (XRD) analysis demonstrated that bioresorbable β-Ca2P2O7 (β-DCP), β-Na2CaP2O7, Na2Mg(PO3)4 phases were formed in the glass matrix depending upon the relative contents of the additives. By adding higher contents of Na2O and TiO2 and using CaO/P2O5 = 1.5-2.0, crystallization of β-DCP and Ca3(PO4)2 (β-TCP), and the formation of a dense structure in the glass ceramics were obtained. The precipitation of these crystals could be well distinguished at a magnification of 4000× and phases were dispersed in areas of micron size. A porous structure may be easily formed after the soluble phases are dissolved in physiological media. These glass ceramics with high CaO/P2O5 ratio, modified by the above mentioned additives are expected to find use as implants for bone replacement/regeneration and drug delivery carriers synergistically, because the soluble phases may act as drug delivery carriers and the porous structure will allow for bone ingrowth.
Original languageEnglish
Pages (from-to)14-21
JournalJournal of Non-Crystalline Solids
Volume272
Issue number1
DOIs
Publication statusPublished - Jul 2000
Externally publishedYes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Fingerprint

Dive into the research topics of 'Crystallization and microstructure analysis of calcium phosphate-based glass ceramics for biomedical applications'. Together they form a unique fingerprint.

Cite this