Covariation of major and minor viral capsid proteins in norovirus genogroup II genotype 4 strains

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

13 Scopus Citations
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Author(s)

  • Martin Chi-Wai Chan
  • Nelson Lee
  • Wing-Shan Ho
  • Carmen Oi-Kwan Law
  • Stephen Kwok-Wing Tsui
  • Joseph Jao-Yiu Sung

Detail(s)

Original languageEnglish
Pages (from-to)1227-1232
Journal / PublicationJournal of Virology
Volume86
Issue number2
Publication statusPublished - Jan 2012

Abstract

We report sequence hypervariability in the viral protein 1 (VP1) interaction domain of VP2 in the norovirus (NoV) genogroup II genotype 4 (GII.4) lineage on 3 levels: (i) the global evolution of pandemic/epidemic strains from the mid-1970s through post-2006, (ii) the local emergence of an epidemic strain, and (iii) an immunocompromised patient chronically shedding NoV. When a quantitative yeast two-hybrid assay was used, VP2 was found to interact with VP1 in a time-ordered, strain-dependent manner among 3 NoV GII.4 strains. Our findings suggest that VP1 and VP2 may covary in virus evolution and that sequence hypervariability of VP2 may be functionally driven. Further investigations are warranted. © 2012, American Society for Microbiology.

Citation Format(s)

Covariation of major and minor viral capsid proteins in norovirus genogroup II genotype 4 strains. / Chan, Martin Chi-Wai; Lee, Nelson; Ho, Wing-Shan; Law, Carmen Oi-Kwan; Lau, Terrence Chi-Kong; Tsui, Stephen Kwok-Wing; Sung, Joseph Jao-Yiu.

In: Journal of Virology, Vol. 86, No. 2, 01.2012, p. 1227-1232.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal