Covalent modification of DNA by α, β-unsaturated aldehydes derived from lipid peroxidation: Recent progress and challenges

X. Wei; H. Yin

doi:10.3109/10715762.2015.1040009

Covalent modification of DNA by α, β-unsaturated aldehydes derived from lipid peroxidation: Recent progress and challenges

X. Wei
, H. Yin

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

34 Citations (Scopus)

Abstract

Oxidative stress-induced lipid peroxidation (LPO) has been associated with human physiology and pathophysiology. LPO generates an array of oxidation products and among them reactive lipid aldehydes have received intensive research attentions due to their roles in modulating functions of biomolecules through covalent modification. Thus, covalent modification of DNA by these reactive lipid electrophiles has been postulated to be partially responsible for the biological roles of LPO. In this review, we summarized recent progress and challenges in studying the roles of covalent modification of DNA including nuclear and mitochondrial DNA by reactive lipid metabolites from LPO. We focused on the novel mechanistic insights into generation of lipid aldehydes from cellular membranes especially mitochondria through LPO. Recent advances in the technological front using mass spectrometry have also been highlighted in the settings of studying DNA damage caused by LPO and its biological relevance. © 2015 Informa UK, Ltd.

Original language	English
Pages (from-to)	905-917
Journal	Free Radical Research
Volume	49
Issue number	7
DOIs	https://doi.org/10.3109/10715762.2015.1040009
Publication status	Published - 1 Jul 2015
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work is supported by grants from the National Natural Science Foundation of China (31170809, 31470831, and 91439103), the National Key Basic Research Program of China (973 Program, #2012CB524905), the Ministry of Science and Technology of China (2012BAK01B00), and the Hundred Talents Program from CAS (2012OHTP07). H.Y. is an Associate Fellow at the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine at Nanjing Medical University.

Research Keywords

4-HNE
Adductomics
DNA modification
Free radicals
Lipid electrophiles
Lipid peroxidation
Mass spectrometry
Mitochondria
Reactive oxygen species

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abstract = "Oxidative stress-induced lipid peroxidation (LPO) has been associated with human physiology and pathophysiology. LPO generates an array of oxidation products and among them reactive lipid aldehydes have received intensive research attentions due to their roles in modulating functions of biomolecules through covalent modification. Thus, covalent modification of DNA by these reactive lipid electrophiles has been postulated to be partially responsible for the biological roles of LPO. In this review, we summarized recent progress and challenges in studying the roles of covalent modification of DNA including nuclear and mitochondrial DNA by reactive lipid metabolites from LPO. We focused on the novel mechanistic insights into generation of lipid aldehydes from cellular membranes especially mitochondria through LPO. Recent advances in the technological front using mass spectrometry have also been highlighted in the settings of studying DNA damage caused by LPO and its biological relevance. {\textcopyright} 2015 Informa UK, Ltd.",

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AU - Yin, H.

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AB - Oxidative stress-induced lipid peroxidation (LPO) has been associated with human physiology and pathophysiology. LPO generates an array of oxidation products and among them reactive lipid aldehydes have received intensive research attentions due to their roles in modulating functions of biomolecules through covalent modification. Thus, covalent modification of DNA by these reactive lipid electrophiles has been postulated to be partially responsible for the biological roles of LPO. In this review, we summarized recent progress and challenges in studying the roles of covalent modification of DNA including nuclear and mitochondrial DNA by reactive lipid metabolites from LPO. We focused on the novel mechanistic insights into generation of lipid aldehydes from cellular membranes especially mitochondria through LPO. Recent advances in the technological front using mass spectrometry have also been highlighted in the settings of studying DNA damage caused by LPO and its biological relevance. © 2015 Informa UK, Ltd.

KW - 4-HNE

KW - Adductomics

KW - DNA modification

KW - Free radicals

KW - Lipid electrophiles

KW - Lipid peroxidation

KW - Mass spectrometry

KW - Mitochondria

KW - Reactive oxygen species

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DO - 10.3109/10715762.2015.1040009

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SN - 1071-5762

VL - 49

SP - 905

EP - 917

JO - Free Radical Research

JF - Free Radical Research

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ER -

Covalent modification of DNA by α, β-unsaturated aldehydes derived from lipid peroxidation: Recent progress and challenges

Abstract

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