Cortical Hemodynamic Response and Connectivity Modulated by Sub-threshold High-Frequency Repetitive Transcranial Magnetic Stimulation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Rihui Li
  • Thomas Potter
  • Jun Wang
  • Zhixi Shi
  • Chushan Wang
  • Lingling Yang
  • Yingchun Zhang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number90
Journal / PublicationFrontiers in Human Neuroscience
Volume13
Online published19 Mar 2019
Publication statusPublished - Mar 2019

Link(s)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) at sub-threshold intensity is a viable clinical strategy to enhance the sensory and motor functions of extremities by increasing or decreasing motor cortical excitability. Despite this, it remains unclear how sub-threshold rTMS modulates brain cortical excitability and connectivity. In this study, we applied functional near-infrared spectroscopy (fNIRS) to investigate the alterations in hemodynamic responses and cortical connectivity patterns that are induced by high-frequency rTMS at a sub-threshold intensity. Forty high-frequency (10 Hz) trains of rTMS at 90% resting motor threshold (RMT) were delivered through a TMS coil placed over 1-2 cm lateral from the vertex. fNIRS signals were acquired from the frontal and bilateral motor areas in healthy volunteers (n = 20) during rTMS administration and at rest. A significant reduction in oxygenated hemoglobin (HbO) concentration was observed in most defined regions of interest (ROls) during the stimulation period (p < 0.05). Decreased functional connectivity within prefrontal areas as well as between symmetrical ROI-pairs was also observed in most participants during the stimulation (p < 0.05). Results suggest that fNIRS imaging is able to provide a reliable measure of regional cortical brain activation that advances our understanding of the manner in which sub-threshold rTMS affects cortical excitability and brain connectivity.

Research Area(s)

  • repetitive transcranial magnetic stimulation, near infrared spectroscopy, hemodynamic response, cortical excitability, brain connectivity

Citation Format(s)

Cortical Hemodynamic Response and Connectivity Modulated by Sub-threshold High-Frequency Repetitive Transcranial Magnetic Stimulation. / Li, Rihui; Potter, Thomas; Wang, Jun; Shi, Zhixi; Wang, Chushan; Yang, Lingling; Chan, Rosa; Zhang, Yingchun.

In: Frontiers in Human Neuroscience, Vol. 13, 90, 03.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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