TY - JOUR
T1 - Cortical effects of deep brain stimulation implications for pathogenesis and treatment of parkinson disease
AU - Li, Qian
AU - Qian, Zhong-Ming
AU - Arbuthnott, Gordon W.
AU - Ke, Ya
AU - Yung, Wing-Ho
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2014/1
Y1 - 2014/1
N2 - High-frequency electrical stimulation that targets the subthalamic nucleus has proved to be beneficial in alleviating the motor symptoms in many patients with Parkinson disease. The mechanism of action for this paradigm of deep brain stimulation is still not fully understood, and this is, in part, attributed to the fact that there are diverse cellular elements at the stimulation site that could bring about local and distal effects. Recent studies in both human and animal models strongly suggest that the activity in the cortex, especially in the motor cortical areas, is directly altered by deep brain stimulation by signals traveling in an antidromic fashion from the subthalamic nucleus. Herein, we discuss the evidence for this proposition, as well as the mechanism by which antidromic activation desynchronizes motor cortical activity. The implications of these new findings for the pathogenesis and treatment of Parkinson disease are highlighted. Copyright 2014 American Medical Association. All rights reserved.
AB - High-frequency electrical stimulation that targets the subthalamic nucleus has proved to be beneficial in alleviating the motor symptoms in many patients with Parkinson disease. The mechanism of action for this paradigm of deep brain stimulation is still not fully understood, and this is, in part, attributed to the fact that there are diverse cellular elements at the stimulation site that could bring about local and distal effects. Recent studies in both human and animal models strongly suggest that the activity in the cortex, especially in the motor cortical areas, is directly altered by deep brain stimulation by signals traveling in an antidromic fashion from the subthalamic nucleus. Herein, we discuss the evidence for this proposition, as well as the mechanism by which antidromic activation desynchronizes motor cortical activity. The implications of these new findings for the pathogenesis and treatment of Parkinson disease are highlighted. Copyright 2014 American Medical Association. All rights reserved.
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U2 - 10.1001/jamaneurol.2013.4221
DO - 10.1001/jamaneurol.2013.4221
M3 - RGC 21 - Publication in refereed journal
C2 - 24189904
SN - 2168-6149
VL - 71
SP - 100
EP - 103
JO - JAMA Neurology
JF - JAMA Neurology
IS - 1
ER -