Copper(I)-catalyzed asymmetric alkene aziridination mediated by PhI(OAc)2 : A facile one-pot procedure

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

59 Scopus Citations
View graph of relations

Author(s)

  • Di Liu
  • Ka-Yee Chan
  • Chi-Sing Lee
  • Ka-Hung Huang
  • Chi-Ming Che

Detail(s)

Original languageEnglish
Pages (from-to)3965-3968
Journal / PublicationTetrahedron Letters
Volume45
Issue number20
Publication statusPublished - 10 May 2004

Abstract

A facile one-pot procedure for copper-catalyzed PhI(OAc) 2-mediated asymmetric alkene aziridination had been developed. Commercially available PhI(OAc)2 and sulfonamides were used to generate the nitrene precursors (PhI=NR) in situ for olefin aziridination. This one-pot procedure had been optimized using 4-nitrobenzenesulfonamide as the nitrene source. With 5mol% of the chiral copper catalyst, these conditions afforded 94% yield of the isolated product with 75% ee. We had also developed a simple and rapid method to monitor the rate of this one-pot aziridination. © 2004 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Copper catalyst, Iodobenzene diacetate, One-pot asymmetric aziridination, Styrene, Sulfonamides

Citation Format(s)

Copper(I)-catalyzed asymmetric alkene aziridination mediated by PhI(OAc)2 : A facile one-pot procedure. / Kwong, Hoi-Lun; Liu, Di; Chan, Ka-Yee; Lee, Chi-Sing; Huang, Ka-Hung; Che, Chi-Ming.

In: Tetrahedron Letters, Vol. 45, No. 20, 10.05.2004, p. 3965-3968.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review