Copper-Catalyzed Asymmetric Hydrosilylation of β-Nitroethyl Aryl Ketones

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)858-862
Journal / PublicationOrganic Letters
Volume22
Issue number3
Online published9 Jan 2020
Publication statusPublished - 7 Feb 2020
Externally publishedYes

Abstract

A copper-catalyzed asymmetric hydrosilylation of β-nitroethyl aryl ketones has been disclosed, and the corresponding chiral alcohols could be obtained in high yields (up to 99% yield) and excellent enantioselectivities (up to 96% ee). Moreover, the reaction worked well on a gram scale with 0.3 mol % of ligand loading, indicating that our protocol has potential applications in the synthesis of important pharmaceuticals such as Tranylcypromine and Ticagrelor. © 2020 American Chemical Society.

Citation Format(s)

Copper-Catalyzed Asymmetric Hydrosilylation of β-Nitroethyl Aryl Ketones. / Zeng, Weijun; Tan, Xuefeng; Yu, Yang et al.
In: Organic Letters, Vol. 22, No. 3, 07.02.2020, p. 858-862.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review