Copper‐Catalyzed Asymmetric Arylation of N‐Heteroaryl Aldimines: Elementary Step of a 1,4‐Insertion

Chunlin Wu; Xurong Qin; Adhitya Mangala Putra Moeljadi; Hajime Hirao; Jianrong Steve Zhou

doi:10.1002/ange.201812646

Copper‐Catalyzed Asymmetric Arylation of N‐Heteroaryl Aldimines: Elementary Step of a 1,4‐Insertion

Chunlin Wu
, Xurong Qin
, Adhitya Mangala Putra Moeljadi
, Hajime Hirao
, Jianrong Steve Zhou^*

^*Corresponding author for this work

Department of Chemistry

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Abstract

Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N‐azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4‐insertion in the reaction pathway, a step in which an aryl‐copper species adds directly across four atoms of C=N−C=N in the N‐azaaryl aldimines.

Original language	English
Pages (from-to)	2731-2735
Journal	Angewandte Chemie
Volume	131
Issue number	9
Online published	15 Jan 2019
DOIs	https://doi.org/10.1002/ange.201812646
Publication status	Published - 25 Feb 2019

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title = "Copper‐Catalyzed Asymmetric Arylation of N‐Heteroaryl Aldimines: Elementary Step of a 1,4‐Insertion",

abstract = "Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N‐azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4‐insertion in the reaction pathway, a step in which an aryl‐copper species adds directly across four atoms of C=N−C=N in the N‐azaaryl aldimines.",

author = "Chunlin Wu and Xurong Qin and Moeljadi, \{Adhitya Mangala Putra\} and Hajime Hirao and Zhou, \{Jianrong Steve\}",

year = "2019",

month = feb,

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doi = "10.1002/ange.201812646",

language = "English",

volume = "131",

pages = "2731--2735",

journal = "Angewandte Chemie",

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publisher = "John Wiley \& Sons",

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TY - JOUR

T1 - Copper‐Catalyzed Asymmetric Arylation of N‐Heteroaryl Aldimines

T2 - Elementary Step of a 1,4‐Insertion

AU - Wu, Chunlin

AU - Qin, Xurong

AU - Moeljadi, Adhitya Mangala Putra

AU - Hirao, Hajime

AU - Zhou, Jianrong Steve

PY - 2019/2/25

Y1 - 2019/2/25

N2 - Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N‐azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4‐insertion in the reaction pathway, a step in which an aryl‐copper species adds directly across four atoms of C=N−C=N in the N‐azaaryl aldimines.

AB - Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N‐azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4‐insertion in the reaction pathway, a step in which an aryl‐copper species adds directly across four atoms of C=N−C=N in the N‐azaaryl aldimines.

U2 - 10.1002/ange.201812646

DO - 10.1002/ange.201812646

M3 - RGC 21 - Publication in refereed journal

SN - 0044-8249

VL - 131

SP - 2731

EP - 2735

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 9

ER -

Copper‐Catalyzed Asymmetric Arylation of N‐Heteroaryl Aldimines: Elementary Step of a 1,4‐Insertion

Abstract

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