Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 12 - Chapter in an edited book (Author)peer-review

12 Scopus Citations
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Author(s)

  • Wenbo Shi
  • Ran Ding
  • Yuan Fang
  • Ruixi Wan
  • Yilin Chen
  • Jianping Jin

Detail(s)

Original languageEnglish
Title of host publicationCullin-RING Ligases and Protein Neddylation
Subtitle of host publicationBiology and Therapeutics
EditorsYi Sun, Wenyi Wei, Jianping Jin
PublisherSpringer
Chapter5
Pages61-78
Number of pages18
ISBN (electronic)978-981-15-1025-0
ISBN (print)978-981-15-1024-3
Publication statusPublished - 2020
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1217
ISSN (Print)0065-2598
ISSN (electronic)2214-8019

Abstract

The cullin-RING ubiquitin ligases comprise the largest subfamily of ubiquitin ligases. They control ubiquitylation and degradation of a large number of protein substrates in eukaryotes. p97 is an ATPase domain-containing protein segregase. It plays essential roles in post-ubiquitylational events in the ubiquitin-proteasome pathway. Together with its cofactors, p97 collaborates with ubiquitin ligases to extract ubiquitylated substrates and deliver them to the proteasome for proteolysis. Here we review the structure, functions, and mechanisms of p97 in cellular protein degradation in coordination with its cofactors and the cullin-RING ubiquitin ligases.

Research Area(s)

  • Cullin-RING ubiquitin ligase, p97, Protein degradation, Ubiquitylation

Citation Format(s)

Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation. / Shi, Wenbo; Ding, Ran; Zhou, Pei Pei et al.
Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics. ed. / Yi Sun; Wenyi Wei; Jianping Jin. Springer, 2020. p. 61-78 (Advances in Experimental Medicine and Biology; Vol. 1217).

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 12 - Chapter in an edited book (Author)peer-review