Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

1 Scopus Citations
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Author(s)

  • Delin Chen
  • Kathy Hiu Laam Po
  • Pilar Blasco
  • Sheng Chen
  • Xuechen Li

Detail(s)

Original languageEnglish
Pages (from-to)4749-4753
Number of pages5
Journal / PublicationOrganic Letters
Volume22
Issue number12
Online published2 Jun 2020
Publication statusPublished - 19 Jun 2020

Abstract

A convergent synthesis via the late-stage serine ligation of naturally occurring calcium-dependent antibiotic CDA3a and its analogues has been developed, which allowed us to readily synthesize the analogues with the variation on the lipid tail. Some analogues were found to show 100−500-fold higher antimicrobial activity than the natural compound CDA3a against drug resistant bacteria. This study will enhance our understanding of CDA3a and provide valuable antibacterial lead candidates for further development.

Citation Format(s)

Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation. / Chen, Delin; Po, Kathy Hiu Laam; Blasco, Pilar; Chen, Sheng; Li, Xuechen.

In: Organic Letters, Vol. 22, No. 12, 19.06.2020, p. 4749-4753.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal