Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2

Claus Schneider; William E. Boeglin; Huiyong Yin; Donald F. Stec; Markus Voehler

doi:10.1021/ja056517y

Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2

Claus Schneider, William E. Boeglin, Huiyong Yin, Donald F. Stec, Markus Voehler

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

30 Citations (Scopus)

Abstract

5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound of a novel group of lipid mediators. Copyright © 2006 American Chemical Society.

Original language	English
Pages (from-to)	720-721
Journal	Journal of the American Chemical Society
Volume	128
Issue number	3
DOIs	https://doi.org/10.1021/ja056517y
Publication status	Published - 25 Jan 2006
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work was supported by NIH Grant GM53638. We thank Drs. Brian Bachmann, Alan Brash, Thomas Harris, and Ned Porter for helpful discussions on the product identification and the mechanism of formation.

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abstract = "5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply oxygenated by COX-2, implicating a cross-pathway interaction. The product is a unique diendoperoxide, potentially representing the parent compound of a novel group of lipid mediators. Copyright {\textcopyright} 2006 American Chemical Society.",

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AU - Voehler, Markus

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Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2

Abstract

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