Controlled release of sirolimus from a multilayered PLGA stent matrix

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)5588-5595
Journal / PublicationBiomaterials
Volume27
Issue number32
Online published1 Aug 2006
Publication statusPublished - Nov 2006
Externally publishedYes

Abstract

The release of sirolimus from a bi-layer biodegradable polymeric film is reported in this study. Approved drug-eluting metal stents use a thin polymer coating to control drug release, but the degree of control is limited. In a fully polymeric stent, the use of multilayers allows a range of release kinetics. A bi-layer system, with PLLA as the supporting layer and PLGA as the drug-eluting layer, was used in this study to simulate release of sirolimus from a stent. The results show that the release of sirolimus is diffusion and degradation-controlled, and that the amount of sirolimus loading does not affect its release kinetics. The release of sirolimus is, however, accelerated by the addition of a plasticizer, such as PEG, as water uptake is increased. An increased water uptake increases polymer degradation, and changes the dominant mode of release to degradation-control. The release of sirolimus can, on the other hand, be retarded by using a coating of a biodegradable polyester with a lauryl ester end group. Therefore, multilayered systems offer many options for controlling sirolimus release over months. © 2006 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Controlled release, Degradation control, Diffusion control, Multilayered, PLGA, Sirolimus

Citation Format(s)

Controlled release of sirolimus from a multilayered PLGA stent matrix. / Wang, Xintong; Venkatraman, Subbu S.; Boey, Freddy Y.C. et al.
In: Biomaterials, Vol. 27, No. 32, 11.2006, p. 5588-5595.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review