Controlled Cell Patterning on Bioactive Surfaces with Special Wettability

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

12 Scopus Citations
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Author(s)

  • Xiaofeng Zhou
  • Yi Hu
  • Lufeng Che
  • Zuankai Wang

Detail(s)

Original languageEnglish
Pages (from-to)440-447
Journal / PublicationJournal of Bionic Engineering
Volume14
Issue number3
Publication statusPublished - Jul 2017

Abstract

The ability to control cell patterning on artificial substrates with various physicochemical properties is of essence for important implications in cytology and biomedical fields. Despite extensive progress, the ability to control the cell-surface interaction is complicated by the complexity in the physiochemical features of bioactive surfaces. In particular, the manifestation of special wettability rendered by the combination of surface roughness and surface chemistry further enriches the cell-surface interaction. Herein we investigated the cell adhesion behaviors of Circulating Tumor Cells (CTCs) on topographically patterned but chemically homogeneous surfaces. Harnessing the distinctive cell adhesion on surfaces with different topography, we further explored the feasibility of controlled cell patterning using periodic lattices of alternative topographies. We envision that our method provides a designer’s toolbox to manage the extracellular environment.

Research Area(s)

  • cell patterning, circulating tumor cells, superhydrophilic, surface chemistry, wettability

Citation Format(s)

Controlled Cell Patterning on Bioactive Surfaces with Special Wettability. / Zhou, Xiaofeng; Li, Jiaqian; Sun, Hongyan et al.

In: Journal of Bionic Engineering, Vol. 14, No. 3, 07.2017, p. 440-447.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review