Control of single cell migration induced by robotically controlled microsource

Hao Yang; Xiangpeng Li; Yong Wang; Dong Sun

doi:10.1109/ROBIO.2015.7419059

Control of single cell migration induced by robotically controlled microsource

Hao Yang
, Xiangpeng Li
, Yong Wang
, Dong Sun

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

1 Citation (Scopus)

Abstract

Cell migration is a cell movement that responds to certain stimuli driven by inner cytoskeleton network. Control of cell migration is a very challenging problem, and successfully addressing the problem will promote many promising biomedical applications. In this paper, we propose the use of a robotically controlled optical tweezers manipulation system to control a single cell to migrate to a desired region with a unified controller. Chemoattractant loaded microsource beads are employed to release the drug to generate gradient field, which induces cell polarization. A new geometric model that formulates the cell to confine within the high motility area while maintaining the microsource bead near the optical trap is established. Based on this model, a potential field function based controller is developed to migrate the cell to a desired region. Simulation and experiments results are presented to illustrate the effectiveness of the proposed approach.

Original language	English
Title of host publication	Proceedings of the 2015 IEEE International Conference on Robotics and Biomimetics
Publisher	IEEE
Pages	1956-1961
ISBN (Print)	9781467396745
DOIs	https://doi.org/10.1109/ROBIO.2015.7419059
Publication status	Published - Dec 2015
Event	2015 IEEE International Conference on Robotics and Biomimetics (IEEE-ROBIO 2015) - Zhuhai, China Duration: 6 Dec 2015 → 9 Dec 2015 https://ieeexplore.ieee.org/xpl/conhome/7397291/proceeding

Conference

Conference	2015 IEEE International Conference on Robotics and Biomimetics (IEEE-ROBIO 2015)
Place	China
City	Zhuhai
Period	6/12/15 → 9/12/15
Internet address	https://ieeexplore.ieee.org/xpl/conhome/7397291/proceeding

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@inproceedings{7b21091f9cb2442d82edd3ca28078304,

title = "Control of single cell migration induced by robotically controlled microsource",

abstract = "Cell migration is a cell movement that responds to certain stimuli driven by inner cytoskeleton network. Control of cell migration is a very challenging problem, and successfully addressing the problem will promote many promising biomedical applications. In this paper, we propose the use of a robotically controlled optical tweezers manipulation system to control a single cell to migrate to a desired region with a unified controller. Chemoattractant loaded microsource beads are employed to release the drug to generate gradient field, which induces cell polarization. A new geometric model that formulates the cell to confine within the high motility area while maintaining the microsource bead near the optical trap is established. Based on this model, a potential field function based controller is developed to migrate the cell to a desired region. Simulation and experiments results are presented to illustrate the effectiveness of the proposed approach.",

author = "Hao Yang and Xiangpeng Li and Yong Wang and Dong Sun",

year = "2015",

month = dec,

doi = "10.1109/ROBIO.2015.7419059",

language = "English",

isbn = "9781467396745",

pages = "1956--1961",

booktitle = "Proceedings of the 2015 IEEE International Conference on Robotics and Biomimetics",

publisher = "IEEE",

address = "United States",

note = "2015 IEEE International Conference on Robotics and Biomimetics (IEEE-ROBIO 2015) ; Conference date: 06-12-2015 Through 09-12-2015",

url = "https://ieeexplore.ieee.org/xpl/conhome/7397291/proceeding",

}

Yang, H, Li, X, Wang, Y & Sun, D 2015, Control of single cell migration induced by robotically controlled microsource. in Proceedings of the 2015 IEEE International Conference on Robotics and Biomimetics., 7419059, IEEE, pp. 1956-1961, 2015 IEEE International Conference on Robotics and Biomimetics (IEEE-ROBIO 2015), Zhuhai, China, 6/12/15. https://doi.org/10.1109/ROBIO.2015.7419059

Control of single cell migration induced by robotically controlled microsource. / Yang, Hao; Li, Xiangpeng; Wang, Yong et al.
Proceedings of the 2015 IEEE International Conference on Robotics and Biomimetics. IEEE, 2015. p. 1956-1961 7419059.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Control of single cell migration induced by robotically controlled microsource

AU - Yang, Hao

AU - Li, Xiangpeng

AU - Wang, Yong

AU - Sun, Dong

PY - 2015/12

Y1 - 2015/12

N2 - Cell migration is a cell movement that responds to certain stimuli driven by inner cytoskeleton network. Control of cell migration is a very challenging problem, and successfully addressing the problem will promote many promising biomedical applications. In this paper, we propose the use of a robotically controlled optical tweezers manipulation system to control a single cell to migrate to a desired region with a unified controller. Chemoattractant loaded microsource beads are employed to release the drug to generate gradient field, which induces cell polarization. A new geometric model that formulates the cell to confine within the high motility area while maintaining the microsource bead near the optical trap is established. Based on this model, a potential field function based controller is developed to migrate the cell to a desired region. Simulation and experiments results are presented to illustrate the effectiveness of the proposed approach.

AB - Cell migration is a cell movement that responds to certain stimuli driven by inner cytoskeleton network. Control of cell migration is a very challenging problem, and successfully addressing the problem will promote many promising biomedical applications. In this paper, we propose the use of a robotically controlled optical tweezers manipulation system to control a single cell to migrate to a desired region with a unified controller. Chemoattractant loaded microsource beads are employed to release the drug to generate gradient field, which induces cell polarization. A new geometric model that formulates the cell to confine within the high motility area while maintaining the microsource bead near the optical trap is established. Based on this model, a potential field function based controller is developed to migrate the cell to a desired region. Simulation and experiments results are presented to illustrate the effectiveness of the proposed approach.

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U2 - 10.1109/ROBIO.2015.7419059

DO - 10.1109/ROBIO.2015.7419059

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781467396745

SP - 1956

EP - 1961

BT - Proceedings of the 2015 IEEE International Conference on Robotics and Biomimetics

PB - IEEE

T2 - 2015 IEEE International Conference on Robotics and Biomimetics (IEEE-ROBIO 2015)

Y2 - 6 December 2015 through 9 December 2015

ER -

Control of single cell migration induced by robotically controlled microsource

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