Contorted acene ribbons for stable and ultrasensitive neural probes

Shayan Louie; Qifeng Jiang; Duncan J. Wisniewski; Si Tong Bao; Honghu Zhang; Kaushik Chivukula; Qiyi Fang; Ashutosh Garudapalli; Scott R. Docherty; Fay Ng; Michael Steigerwald; Yu Zhong; Dion Khodagholy; Colin Nuckolls

doi:10.1126/sciadv.adu2356

Contorted acene ribbons for stable and ultrasensitive neural probes

Shayan Louie (Co-first Author), Qifeng Jiang^* (Co-first Author), Duncan J. Wisniewski (Co-first Author), Si Tong Bao, Honghu Zhang, Kaushik Chivukula, Qiyi Fang, Ashutosh Garudapalli, Scott R. Docherty, Fay Ng, Michael Steigerwald, Yu Zhong, Dion Khodagholy^*, Colin Nuckolls^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

Abstract

Organic materials that conduct both electrons and ions are integral to implantable bioelectronics because of their conformable nature. There is a dearth of these materials that are highly sensitive to cations, which are the majority ions on the surface of neurons. This manuscript offers a solution using an extended ribbon structure that is defect-free, providing high electronic mobility along its fused backbone, while the edge structure of these ribbons promotes high ionic conductivity. We incorporated these mixed ion/electron conductors into neural probes and implanted them in a rodent brain where they offer a suite of useful properties: high cation sensitivity, stability over several weeks after implantation, and biocompatibility. These materials represent an innovative class of implantable biosensors. Copyright © 2025 The Authors, some rights reserved.

Original language	English
Article number	eadu2356
Number of pages	7
Journal	Science Advances
Volume	11
Issue number	14
Online published	2 Apr 2025
DOIs	https://doi.org/10.1126/sciadv.adu2356
Publication status	Published - 4 Apr 2025
Externally published	Yes

Funding

C.N. thanks S. Buckler and D. Buckler for the generous support. The NMR measurements reported in this publication was supported by the Office of The Director of the National Institutes of Health under award number S10OD026749. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research used the Complex Materials Scattering (CMS) 11-BM beamline of the National Synchrotron Light Source II, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under contract no. DE-SC0012704.

Publisher's Copyright Statement

This full text is made available under CC-BY-NC 4.0. https://creativecommons.org/licenses/by-nc/4.0/

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abstract = "Organic materials that conduct both electrons and ions are integral to implantable bioelectronics because of their conformable nature. There is a dearth of these materials that are highly sensitive to cations, which are the majority ions on the surface of neurons. This manuscript offers a solution using an extended ribbon structure that is defect-free, providing high electronic mobility along its fused backbone, while the edge structure of these ribbons promotes high ionic conductivity. We incorporated these mixed ion/electron conductors into neural probes and implanted them in a rodent brain where they offer a suite of useful properties: high cation sensitivity, stability over several weeks after implantation, and biocompatibility. These materials represent an innovative class of implantable biosensors. Copyright {\textcopyright} 2025 The Authors, some rights reserved.",

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AU - Louie, Shayan

AU - Jiang, Qifeng

AU - Wisniewski, Duncan J.

AU - Bao, Si Tong

AU - Zhang, Honghu

AU - Chivukula, Kaushik

AU - Fang, Qiyi

AU - Garudapalli, Ashutosh

AU - Docherty, Scott R.

AU - Ng, Fay

AU - Steigerwald, Michael

AU - Zhong, Yu

AU - Khodagholy, Dion

AU - Nuckolls, Colin

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AB - Organic materials that conduct both electrons and ions are integral to implantable bioelectronics because of their conformable nature. There is a dearth of these materials that are highly sensitive to cations, which are the majority ions on the surface of neurons. This manuscript offers a solution using an extended ribbon structure that is defect-free, providing high electronic mobility along its fused backbone, while the edge structure of these ribbons promotes high ionic conductivity. We incorporated these mixed ion/electron conductors into neural probes and implanted them in a rodent brain where they offer a suite of useful properties: high cation sensitivity, stability over several weeks after implantation, and biocompatibility. These materials represent an innovative class of implantable biosensors. Copyright © 2025 The Authors, some rights reserved.

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Contorted acene ribbons for stable and ultrasensitive neural probes

Abstract

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