Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)7378-7394
Number of pages17
Journal / PublicationChemical Society Reviews
Volume50
Issue number13
Online published21 May 2021
Publication statusPublished - 7 Jul 2021
Externally publishedYes

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Abstract

Large quantities of fluorinated gases are generated as intermediates or byproducts from fluorinated polymer production annually, and they are effective ozone depleting substances or greenhouse gases. On the other hand, the incorporation of fluoroalkyl groups into drug molecules or bioactive compounds has been shown to enhance biological properties such as the bioavailability, binding selectivity, and metabolic stability. Extraction of fluoroalkyl sources, including trifluoromethyl and difluoromethyl groups, from the fluorinated gases is highly desirable, yet challenging under regular batch reaction conditions. Flow chemistry is an emerging and promising technique to address long-standing challenges in gas-liquid batch reactions such as insufficient interfacial contact and scalability issues. In this review, we highlight recent advances in continuous flow strategies toward enabling the use of fluorinated greenhouse gases in organic synthesis. © 2021 The Royal Society of Chemistry.

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Citation Format(s)

Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations. / Fu, Wai Chung; MacQueen, Preston M.; Jamison, Timothy F.
In: Chemical Society Reviews, Vol. 50, No. 13, 07.07.2021, p. 7378-7394.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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