CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS

Ming Wang; Hua Liang Leo; Chwee Teck Lim; Chia-Hung Chen

CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS

Ming Wang
, Hua Liang Leo
, Chwee Teck Lim
, Chia-Hung Chen^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Secretomics, especially protease secretions from adherent cells, is important in determining the mobility of cells and is usually correlated to cancer metastasis. Mechanical properties of extracellular matrix (ECM) are pivotal in influencing cell secretions by modifying intracellular transportation, endo/exocytosis, and transcription of proteins. Therefore, the study of individual cells interacting with varying matrix stiffness in terms of protease secretion could provide useful insight in understanding cancer migration/metastasis.

Original language	English
Title of host publication	μTAS 2017
Subtitle of host publication	The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	912-913
ISBN (Electronic)	9780692941836
Publication status	Published - Oct 2017
Externally published	Yes
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) - Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017 https://archive.cbmsociety.org/utas/uTAS2017.zip

Publication series

Name	International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS
Publisher	Chemical and Biological Microsystems Society
ISSN (Electronic)	1556-5904

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
Place	United States
City	Savannah
Period	22/10/17 → 26/10/17
Internet address	https://archive.cbmsociety.org/utas/uTAS2017.zip

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Cell-matrix interaction
Continuous flow detection
Secretomics
Single adherent cell assay

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Wang, M., Leo, H. L., Lim, C. T., & Chen, C.-H. (2017). CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS. In μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 912-913). (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS). Chemical and Biological Microsystems Society.

Wang, Ming ; Leo, Hua Liang ; Lim, Chwee Teck et al. / CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS. μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2017. pp. 912-913 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

@inproceedings{d7fde0791c9b43d8bd7c899c32289bd2,

title = "CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS",

abstract = "Secretomics, especially protease secretions from adherent cells, is important in determining the mobility of cells and is usually correlated to cancer metastasis. Mechanical properties of extracellular matrix (ECM) are pivotal in influencing cell secretions by modifying intracellular transportation, endo/exocytosis, and transcription of proteins. Therefore, the study of individual cells interacting with varying matrix stiffness in terms of protease secretion could provide useful insight in understanding cancer migration/metastasis.",

keywords = "Cell-matrix interaction, Continuous flow detection, Secretomics, Single adherent cell assay",

author = "Ming Wang and Leo, \{Hua Liang\} and Lim, \{Chwee Teck\} and Chia-Hung Chen",

year = "2017",

month = oct,

language = "English",

series = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS",

publisher = "Chemical and Biological Microsystems Society",

pages = "912--913",

booktitle = "μTAS 2017",

note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) ; Conference date: 22-10-2017 Through 26-10-2017",

url = "https://archive.cbmsociety.org/utas/uTAS2017.zip",

}

Wang, M, Leo, HL, Lim, CT & Chen, C-H 2017, CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS. in μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS, Chemical and Biological Microsystems Society, pp. 912-913, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah, Georgia, United States, 22/10/17.

CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS. / Wang, Ming; Leo, Hua Liang; Lim, Chwee Teck et al.
μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2017. p. 912-913 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS

AU - Wang, Ming

AU - Leo, Hua Liang

AU - Lim, Chwee Teck

AU - Chen, Chia-Hung

PY - 2017/10

Y1 - 2017/10

N2 - Secretomics, especially protease secretions from adherent cells, is important in determining the mobility of cells and is usually correlated to cancer metastasis. Mechanical properties of extracellular matrix (ECM) are pivotal in influencing cell secretions by modifying intracellular transportation, endo/exocytosis, and transcription of proteins. Therefore, the study of individual cells interacting with varying matrix stiffness in terms of protease secretion could provide useful insight in understanding cancer migration/metastasis.

AB - Secretomics, especially protease secretions from adherent cells, is important in determining the mobility of cells and is usually correlated to cancer metastasis. Mechanical properties of extracellular matrix (ECM) are pivotal in influencing cell secretions by modifying intracellular transportation, endo/exocytosis, and transcription of proteins. Therefore, the study of individual cells interacting with varying matrix stiffness in terms of protease secretion could provide useful insight in understanding cancer migration/metastasis.

KW - Cell-matrix interaction

KW - Continuous flow detection

KW - Secretomics

KW - Single adherent cell assay

UR - https://www.scopus.com/pages/publications/85079586062

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85079586062&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

T3 - International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

SP - 912

EP - 913

BT - μTAS 2017

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)

Y2 - 22 October 2017 through 26 October 2017

ER -

Wang M, Leo HL, Lim CT, Chen CH. CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS. In μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2017. p. 912-913. (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

CONTINUOUS FLOW MICROFLUIDICS FOR ADHERENT SINGLE CELL SECRETOMICS PROFILING IN RESPONSE TO VARIOUS MATRIX STIFFNESS

Abstract

Publication series

Conference

UN SDGs

Research Keywords

Other Access Options

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