Continuous flow cell-cell interaction screening via a sequental injector

Weikang Nicholas Lin; Shih-Chung Wei; Matthew Zirui Tay; Lu Ri; Chia-Hung Chen

Continuous flow cell-cell interaction screening via a sequental injector

Weikang Nicholas Lin^*, Shih-Chung Wei, Matthew Zirui Tay, Lu Ri, Chia-Hung Chen

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

A high-throughput, high efficiency workflow for the sequential delivery of cells into droplet emulsions was demonstrated using picoinjection. Herein, we propose a workflow to increase the consistency of delivery of heterogeneous cell suspensions into droplets by packing cells prior to picoinjection. A cell delivery efficiency of ≈70% was achieved, suggesting its usefulness in the study of cell-cell interactions at a high throughput.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)
Publisher	Chemical and Biological Microsystems Society
Pages	965-966
ISBN (Electronic)	9781713818526
ISBN (Print)	9781733419000
Publication status	Published - Oct 2019
Externally published	Yes
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019) - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 https://cbmsociety.org/microtas/microtas2019/

Publication series

Name	International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)
Abbreviated title	MicroTAS 2019
Place	Switzerland
City	Basel
Period	27/10/19 → 31/10/19
Internet address	https://cbmsociety.org/microtas/microtas2019/

Research Keywords

Cell delivery
Cell-cell interaction
Droplet microfluidics
Picoinjector

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Lin, W. N., Wei, S.-C., Tay, M. Z., Ri, L., & Chen, C.-H. (2019). Continuous flow cell-cell interaction screening via a sequental injector. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019) (pp. 965-966). (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS). Chemical and Biological Microsystems Society.

Lin, Weikang Nicholas ; Wei, Shih-Chung ; Tay, Matthew Zirui et al. / Continuous flow cell-cell interaction screening via a sequental injector. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). Chemical and Biological Microsystems Society, 2019. pp. 965-966 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

@inproceedings{b4b8739fa1824069ae9b40c096403e2a,

title = "Continuous flow cell-cell interaction screening via a sequental injector",

abstract = "A high-throughput, high efficiency workflow for the sequential delivery of cells into droplet emulsions was demonstrated using picoinjection. Herein, we propose a workflow to increase the consistency of delivery of heterogeneous cell suspensions into droplets by packing cells prior to picoinjection. A cell delivery efficiency of ≈70% was achieved, suggesting its usefulness in the study of cell-cell interactions at a high throughput.",

keywords = "Cell delivery, Cell-cell interaction, Droplet microfluidics, Picoinjector",

author = "Lin, {Weikang Nicholas} and Shih-Chung Wei and Tay, {Matthew Zirui} and Lu Ri and Chia-Hung Chen",

year = "2019",

month = oct,

language = "English",

isbn = "9781733419000",

series = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS",

publisher = "Chemical and Biological Microsystems Society",

pages = "965--966",

booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)",

note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

url = "https://cbmsociety.org/microtas/microtas2019/",

}

Lin, WN, Wei, S-C, Tay, MZ, Ri, L & Chen, C-H 2019, Continuous flow cell-cell interaction screening via a sequental injector. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS, Chemical and Biological Microsystems Society, pp. 965-966, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), Basel, Switzerland, 27/10/19.

Continuous flow cell-cell interaction screening via a sequental injector. / Lin, Weikang Nicholas; Wei, Shih-Chung; Tay, Matthew Zirui et al.
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). Chemical and Biological Microsystems Society, 2019. p. 965-966 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Continuous flow cell-cell interaction screening via a sequental injector

AU - Lin, Weikang Nicholas

AU - Wei, Shih-Chung

AU - Tay, Matthew Zirui

AU - Ri, Lu

AU - Chen, Chia-Hung

PY - 2019/10

Y1 - 2019/10

N2 - A high-throughput, high efficiency workflow for the sequential delivery of cells into droplet emulsions was demonstrated using picoinjection. Herein, we propose a workflow to increase the consistency of delivery of heterogeneous cell suspensions into droplets by packing cells prior to picoinjection. A cell delivery efficiency of ≈70% was achieved, suggesting its usefulness in the study of cell-cell interactions at a high throughput.

AB - A high-throughput, high efficiency workflow for the sequential delivery of cells into droplet emulsions was demonstrated using picoinjection. Herein, we propose a workflow to increase the consistency of delivery of heterogeneous cell suspensions into droplets by packing cells prior to picoinjection. A cell delivery efficiency of ≈70% was achieved, suggesting its usefulness in the study of cell-cell interactions at a high throughput.

KW - Cell delivery

KW - Cell-cell interaction

KW - Droplet microfluidics

KW - Picoinjector

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85094940389&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781733419000

T3 - International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

SP - 965

EP - 966

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)

PB - Chemical and Biological Microsystems Society

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)

Y2 - 27 October 2019 through 31 October 2019

ER -

Lin WN, Wei SC, Tay MZ, Ri L, Chen CH. Continuous flow cell-cell interaction screening via a sequental injector. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). Chemical and Biological Microsystems Society. 2019. p. 965-966. (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

Continuous flow cell-cell interaction screening via a sequental injector

Abstract

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Research Keywords

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