Continuous Blood Pressure Measurement From Invasive to Unobtrusive: Celebration of 200th Birth Anniversary of Carl Ludwig

Xiao-Rong Ding, Ni Zhao, Guang-Zhong Yang, Roderic I. Pettigrew, Benny Lo, Fen Miao, Ye Li, Jing Liu, Yuan-Ting Zhang*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

146 Citations (Scopus)

Abstract

The year 2016 marks the 200th birth anniversary of Carl Friedrich Wilhelm Ludwig (1816-1895). As one of the most remarkable scientists, Ludwig invented the kymograph, which for the first time enabled the recording of continuous blood pressure (BP), opening the door to the modern study of physiology. Almost a century later, intraarterial BP monitoring through an arterial line has been used clinically. Subsequently, arterial tonometry and volume clamp method were developed and applied in continuous BP measurement in a noninvasive way. In the last two decades, additional efforts have been made to transform the method of unobtrusive continuous BP monitoring without the use of a cuff. This review summarizes the key milestones in continuous BP measurement; that is, kymograph, intraarterial BP monitoring, arterial tonometry, volume clamp method, and cuffless BP technologies. Our emphasis is on recent studies of unobtrusive BP measurements as well as on challenges and future directions.
Original languageEnglish
Article number7676313
Pages (from-to)1455-1465
JournalIEEE Journal of Biomedical and Health Informatics
Volume20
Issue number6
Online published25 Oct 2016
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

Research Keywords

  • Carl ludwig
  • continuous
  • cuffless blood pressure (BP)
  • kymograph
  • unobtrusive

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