Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

Lili Huang; Lawrence Cho-Cheung Lee; Justin Shum; Guang-Xi Xu; Kenneth Kam-Wing Lo

doi:10.1039/d4cc01824a

Author(s)

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	6186-6189
Journal / Publication	Chemical Communications (London)
Volume	60
Issue number	48
Online published	10 May 2024
Publication status	Published - 18 Jun 2024

Link(s)

DOI	DOI https://doi.org/10.1039/d4cc01824a Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85194395263&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(e05e3c37-5f9c-428f-a387-ded9c5f1aafb).html

Abstract

Luminescent cyclometallated iridium(iii) complexes bearing a 2-formylphenylboronic acid moiety were designed; one of the complexes was utilised to modify peptides containing an N-terminal cysteine to afford luminescent conjugates with selective organelle-targeting or furin-responsive properties. © 2024 The Royal Society of Chemistry.

Citation Format(s)

[ RIS ] [ BibTeX ]

Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy. / Huang, Lili ; Lee, Lawrence Cho-Cheung ; Shum, Justin et al.
In: Chemical Communications (London), Vol. 60, No. 48, 18.06.2024, p. 6186-6189.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Huang, L , Lee, LC-C , Shum, J , Xu, G-X & Lo, KK-W 2024, 'Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy', Chemical Communications (London), vol. 60, no. 48, pp. 6186-6189. https://doi.org/10.1039/d4cc01824a

Huang, L., Lee, L. C.-C., Shum, J., Xu, G.-X., & Lo, K. K.-W. (2024). Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy. Chemical Communications (London), 60(48), 6186-6189. https://doi.org/10.1039/d4cc01824a

Huang L , Lee LCC , Shum J , Xu GX , Lo KKW. Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy. Chemical Communications (London). 2024 Jun 18;60(48):6186-6189. Epub 2024 May 10. doi: 10.1039/d4cc01824a

Huang, Lili ; Lee, Lawrence Cho-Cheung ; Shum, Justin et al. / Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy. In: Chemical Communications (London). 2024 ; Vol. 60, No. 48. pp. 6186-6189.