Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Yimin Guo
  • Weimin Liu
  • Jie Sha
  • Xuewei Li
  • Haohui Ren
  • Jiasheng Wu
  • Pengfei Wang

Detail(s)

Original languageEnglish
Article number122698
Journal / PublicationSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume296
Online published2 Apr 2023
Publication statusPublished - 5 Aug 2023

Abstract

The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their π-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2. © 2023 Elsevier B.V.

Research Area(s)

  • Coumarin, Lipid droplet-targeting, Near-infrared emission, Photodynamic effect, Singlet-atom replacement

Citation Format(s)

Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission. / Guo, Yimin; Liu, Weimin; Sha, Jie et al.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 296, 122698, 05.08.2023.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review