Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

Yimin Guo; Weimin Liu; Jie Sha; Xuewei Li; Haohui Ren; Jiasheng Wu; Wenjun Zhang; Chun-Sing Lee; Pengfei Wang

doi:10.1016/j.saa.2023.122698

Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

Yimin Guo, Weimin Liu^*, Jie Sha, Xuewei Li, Haohui Ren, Jiasheng Wu, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

6 Citations (Scopus)

Abstract

The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their π-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2. © 2023 Elsevier B.V.

Original language	English
Article number	122698
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	296
Online published	2 Apr 2023
DOIs	https://doi.org/10.1016/j.saa.2023.122698
Publication status	Published - 5 Aug 2023

Research Keywords

Coumarin
Lipid droplet-targeting
Near-infrared emission
Photodynamic effect
Singlet-atom replacement

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.saa.2023.122698

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@article{51c24616bd75450d819299c7e11c3871,

title = "Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission",

abstract = "The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their π-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2. {\textcopyright} 2023 Elsevier B.V.",

keywords = "Coumarin, Lipid droplet-targeting, Near-infrared emission, Photodynamic effect, Singlet-atom replacement",

author = "Yimin Guo and Weimin Liu and Jie Sha and Xuewei Li and Haohui Ren and Jiasheng Wu and Wenjun Zhang and Chun-Sing Lee and Pengfei Wang",

year = "2023",

month = aug,

day = "5",

doi = "10.1016/j.saa.2023.122698",

language = "English",

volume = "296",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

issn = "1386-1425",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

AU - Guo, Yimin

AU - Liu, Weimin

AU - Sha, Jie

AU - Li, Xuewei

AU - Ren, Haohui

AU - Wu, Jiasheng

AU - Zhang, Wenjun

AU - Lee, Chun-Sing

AU - Wang, Pengfei

PY - 2023/8/5

Y1 - 2023/8/5

N2 - The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their π-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2. © 2023 Elsevier B.V.

AB - The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their π-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2. © 2023 Elsevier B.V.

KW - Coumarin

KW - Lipid droplet-targeting

KW - Near-infrared emission

KW - Photodynamic effect

KW - Singlet-atom replacement

UR - http://www.scopus.com/inward/record.url?scp=85151756796&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85151756796&origin=recordpage

U2 - 10.1016/j.saa.2023.122698

DO - 10.1016/j.saa.2023.122698

M3 - RGC 21 - Publication in refereed journal

SN - 1386-1425

VL - 296

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

M1 - 122698

ER -

Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

Abstract

Research Keywords

UN SDGs

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