Complex bioactive alkaloid-type polycycles through efficient catalytic asymmetric multicomponent aza-diels-alder reaction of indoles with oxetane as directing group
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 2027-2031 |
| Journal / Publication | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 7 |
| Publication status | Published - 11 Feb 2013 |
Link(s)
Abstract
Starting from three achiral compounds, the title reaction provides rapid access to a variety of molecules that contain indoline, tetrahydroquinoline, and tetrahydroisoquinoline moieties (see scheme). The process features the efficient formation of multiple new bonds and chiral centers, excellent stereoselectivity, oxetane desymmetrization, and easy product purification through filtration. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Research Area(s)
- alkaloids, asymmetric catalysis, cyclization, polycycles, strained molecules
Citation Format(s)
Complex bioactive alkaloid-type polycycles through efficient catalytic asymmetric multicomponent aza-diels-alder reaction of indoles with oxetane as directing group. / Chen, Zhilong; Wang, Beilei; Wang, Zhaobin et al.
In: Angewandte Chemie - International Edition, Vol. 52, No. 7, 11.02.2013, p. 2027-2031.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
