Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Qingyou Xia
  • Yiran Guo
  • Ze Zhang
  • Zhaoling Xuan
  • Zhuo Li
  • Fangyin Dai
  • Yingrui Li
  • Daojun Cheng
  • Ruiqiang Li
  • Tingcai Cheng
  • Tao Jiang
  • Celine Becquet
  • Xun Xu
  • Chun Liu
  • Xingfu Zha
  • Wei Fan
  • Ying Lin
  • Yihong Shen
  • Lan Jiang
  • Jeffrey Jensen
  • Ines Hellmann
  • Si Tang
  • Ping Zhao
  • Hanfu Xu
  • Chang Yu
  • Guojie Zhang
  • Jianjun Cao
  • Shiping Liu
  • Ningjia He
  • Yan Zhou
  • Hui Liu
  • Jing Zhao
  • Chen Ye
  • Zhouhe Du
  • Guoqing Pan
  • Aichun Zhao
  • Haojing Shao
  • Wei Zeng
  • Ping Wu
  • Chunfeng Li
  • Minimi Pan
  • Jingjing Li
  • Xuyang Yin
  • Dawei Li
  • Juan Wang
  • Huisong Zheng
  • Wen Wang
  • Xiuqing Zhang
  • Songgang Li
  • Huanming Yang
  • Cheng Lu
  • Rasmus Nielsen
  • Zeyang Zhou
  • Jian Wang
  • Zhonghuai Xiang
  • Jun Wang

Detail(s)

Original languageEnglish
Pages (from-to)433-436
Number of pages4
Journal / PublicationScience (New York, N.Y.)
Volume326
Issue number5951
Publication statusPublished - 16 Oct 2009
Externally publishedYes

Abstract

A single-base pair resolution silkworm genetic variation map was constructed from 40 domesticated and wild silkworms, each sequenced to approximately threefold coverage, representing 99.88% of the genome. We identified ~16 million single-nucleotide polymorphisms, many indels, and structural variations. We find that the domesticated silkworms are clearly genetically differentiated from the wild ones, but they have maintained large levels of genetic variability, suggesting a short domestication event involving a large number of individuals. We also identified signals of selection at 354 candidate genes that may have been important during domestication, some of which have enriched expression in the silk gland, midgut, and testis. These data add to our understanding of the domestication processes and may have applications in devising pest control strategies and advancing the use of silkworms as efficient bioreactors.

Research Area(s)

  • Animals, Bombyx/classification, Digestive System/metabolism, Exocrine Glands/metabolism, Female, Gene Expression, Genes, Insect, Genetic Variation, Genome, Insect, INDEL Mutation, Linkage Disequilibrium, Male, Phylogeny, Polymorphism, Single Nucleotide, Principal Component Analysis, Selection, Genetic, Sequence Analysis, DNA, Testis/metabolism

Citation Format(s)

Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). / Xia, Qingyou; Guo, Yiran; Zhang, Ze; Li, Dong; Xuan, Zhaoling; Li, Zhuo; Dai, Fangyin; Li, Yingrui; Cheng, Daojun; Li, Ruiqiang; Cheng, Tingcai; Jiang, Tao; Becquet, Celine; Xu, Xun; Liu, Chun; Zha, Xingfu; Fan, Wei; Lin, Ying; Shen, Yihong; Jiang, Lan; Jensen, Jeffrey; Hellmann, Ines; Tang, Si; Zhao, Ping; Xu, Hanfu; Yu, Chang; Zhang, Guojie; Li, Jun; Cao, Jianjun; Liu, Shiping; He, Ningjia; Zhou, Yan; Liu, Hui; Zhao, Jing; Ye, Chen; Du, Zhouhe; Pan, Guoqing; Zhao, Aichun; Shao, Haojing; Zeng, Wei; Wu, Ping; Li, Chunfeng; Pan, Minimi; Li, Jingjing; Yin, Xuyang; Li, Dawei; Wang, Juan; Zheng, Huisong; Wang, Wen; Zhang, Xiuqing; Li, Songgang; Yang, Huanming; Lu, Cheng; Nielsen, Rasmus; Zhou, Zeyang; Wang, Jian; Xiang, Zhonghuai; Wang, Jun.

In: Science (New York, N.Y.), Vol. 326, No. 5951, 16.10.2009, p. 433-436.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal