Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati

Alexandra Kay; Lara Boland; Sarah E. Kidd; Julia A. Beatty; Jessica J. Talbot; Vanessa R. Barrs

doi:10.1016/j.mmcr.2021.08.005

Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati

Alexandra Kay (Co-first Author), Lara Boland (Co-first Author), Sarah E. Kidd, Julia A. Beatty, Jessica J. Talbot, Vanessa R. Barrs^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

9 Citations (Scopus)

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Abstract

Cryptic species in Aspergillus section Fumigati are increasingly reported to cause invasive aspergillosis in humans and animals. These infections are often refractory to treatment because of intrinsic antifungal resistance. We report two cases of invasive fungal rhinosinusitis in domestic cats caused by A. udagawae and A. felis. Clinical signs resolved after combined therapy including posaconazole, caspofungin and terbinafine. Both cases remained asymptomatic more than 2 years from initial presentation.

Original language	English
Pages (from-to)	13-17
Journal	Medical Mycology Case Reports
Volume	34
Online published	2 Sept 2021
DOIs	https://doi.org/10.1016/j.mmcr.2021.08.005
Publication status	Published - Dec 2021

Research Keywords

Aspergillosis
Caspofungin
Cryptic species
Sino-nasal
Sino-orbital

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This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/

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title = "Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati",

abstract = "Cryptic species in Aspergillus section Fumigati are increasingly reported to cause invasive aspergillosis in humans and animals. These infections are often refractory to treatment because of intrinsic antifungal resistance. We report two cases of invasive fungal rhinosinusitis in domestic cats caused by A. udagawae and A. felis. Clinical signs resolved after combined therapy including posaconazole, caspofungin and terbinafine. Both cases remained asymptomatic more than 2 years from initial presentation.",

keywords = "Aspergillosis, Caspofungin, Cryptic species, Sino-nasal, Sino-orbital",

author = "Alexandra Kay and Lara Boland and Kidd, {Sarah E.} and Beatty, {Julia A.} and Talbot, {Jessica J.} and Barrs, {Vanessa R.}",

year = "2021",

month = dec,

doi = "10.1016/j.mmcr.2021.08.005",

language = "English",

volume = "34",

pages = "13--17",

journal = "Medical Mycology Case Reports",

issn = "2211-7539",

publisher = "Elsevier B.V.",

}

Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati. / Kay, Alexandra (Co-first Author); Boland, Lara (Co-first Author); Kidd, Sarah E. et al.
In: Medical Mycology Case Reports, Vol. 34, 12.2021, p. 13-17.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati

AU - Kay, Alexandra

AU - Boland, Lara

AU - Kidd, Sarah E.

AU - Beatty, Julia A.

AU - Talbot, Jessica J.

AU - Barrs, Vanessa R.

PY - 2021/12

Y1 - 2021/12

N2 - Cryptic species in Aspergillus section Fumigati are increasingly reported to cause invasive aspergillosis in humans and animals. These infections are often refractory to treatment because of intrinsic antifungal resistance. We report two cases of invasive fungal rhinosinusitis in domestic cats caused by A. udagawae and A. felis. Clinical signs resolved after combined therapy including posaconazole, caspofungin and terbinafine. Both cases remained asymptomatic more than 2 years from initial presentation.

AB - Cryptic species in Aspergillus section Fumigati are increasingly reported to cause invasive aspergillosis in humans and animals. These infections are often refractory to treatment because of intrinsic antifungal resistance. We report two cases of invasive fungal rhinosinusitis in domestic cats caused by A. udagawae and A. felis. Clinical signs resolved after combined therapy including posaconazole, caspofungin and terbinafine. Both cases remained asymptomatic more than 2 years from initial presentation.

KW - Aspergillosis

KW - Caspofungin

KW - Cryptic species

KW - Sino-nasal

KW - Sino-orbital

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U2 - 10.1016/j.mmcr.2021.08.005

DO - 10.1016/j.mmcr.2021.08.005

M3 - RGC 21 - Publication in refereed journal

C2 - 34540573

SN - 2211-7539

VL - 34

SP - 13

EP - 17

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

ER -

Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati

Abstract

Research Keywords

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