Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Fang Liu; Yingzhi Luo; Huan Chen; Shengjing Xu; Dongyan Zhang; Hong Sang; Chenjie Xu; Min Zhang

doi:10.1039/d2na00604a

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Fang Liu, Yingzhi Luo, Huan Chen, Shengjing Xu, Dongyan Zhang, Hong Sang^*, Chenjie Xu^*, Min Zhang^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

11 Citations (Scopus)

49 Downloads (CityUHK Scholars)

Abstract

Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles. Therefore, this article examines this key point on a rabbit ear hypertrophic scar model. We monitor the thickness of the scars, and the expression of α-SMA and Ki-67 protein, and TGF-β1 mRNA in a period of 42 days. Among microneedles made of 6 polymeric materials and stainless steel, polymethylmethacrylate microneedles present superiority in all aspects including the reduction of tissue fibrosis, and the expression of α-SMA, Ki-67 protein and TGF-β1 mRNA. On the other hand, polycarbonates, polyurethane, and polylactic-co-glycolic acid microneedles could suppress three biomarker expressions.

© 2023 The Author(s).

Original language	English
Pages (from-to)	927-933
Journal	Nanoscale Advances
Volume	5
Issue number	3
Online published	23 Dec 2022
DOIs	https://doi.org/10.1039/d2na00604a
Publication status	Published - 7 Feb 2023

Funding

This work was supported by the National Institutes of Health of China (AI118898). C. X. acknowledges the funding support from the City University of Hong Kong (9610472, 7020029), General Research Fund (GRF) from the University Grant Committee of Hong Kong (UGC) and the Research Grant Council (RGC) (CityU 11202021).

Research Keywords

PRACTICAL GUIDELINES
MANAGEMENT

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This full text is made available under CC-BY-NC 3.0. https://creativecommons.org/licenses/by-nc/3.0/

RGC Funding Information

RGC-funded

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title = "Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model",

abstract = "Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles. Therefore, this article examines this key point on a rabbit ear hypertrophic scar model. We monitor the thickness of the scars, and the expression of α-SMA and Ki-67 protein, and TGF-β1 mRNA in a period of 42 days. Among microneedles made of 6 polymeric materials and stainless steel, polymethylmethacrylate microneedles present superiority in all aspects including the reduction of tissue fibrosis, and the expression of α-SMA, Ki-67 protein and TGF-β1 mRNA. On the other hand, polycarbonates, polyurethane, and polylactic-co-glycolic acid microneedles could suppress three biomarker expressions.{\textcopyright} 2023 The Author(s).",

keywords = "PRACTICAL GUIDELINES, MANAGEMENT",

author = "Fang Liu and Yingzhi Luo and Huan Chen and Shengjing Xu and Dongyan Zhang and Hong Sang and Chenjie Xu and Min Zhang",

year = "2023",

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doi = "10.1039/d2na00604a",

language = "English",

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T1 - Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

AU - Liu, Fang

AU - Luo, Yingzhi

AU - Chen, Huan

AU - Xu, Shengjing

AU - Zhang, Dongyan

AU - Sang, Hong

AU - Xu, Chenjie

AU - Zhang, Min

PY - 2023/2/7

Y1 - 2023/2/7

N2 - Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles. Therefore, this article examines this key point on a rabbit ear hypertrophic scar model. We monitor the thickness of the scars, and the expression of α-SMA and Ki-67 protein, and TGF-β1 mRNA in a period of 42 days. Among microneedles made of 6 polymeric materials and stainless steel, polymethylmethacrylate microneedles present superiority in all aspects including the reduction of tissue fibrosis, and the expression of α-SMA, Ki-67 protein and TGF-β1 mRNA. On the other hand, polycarbonates, polyurethane, and polylactic-co-glycolic acid microneedles could suppress three biomarker expressions.© 2023 The Author(s).

AB - Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles. Therefore, this article examines this key point on a rabbit ear hypertrophic scar model. We monitor the thickness of the scars, and the expression of α-SMA and Ki-67 protein, and TGF-β1 mRNA in a period of 42 days. Among microneedles made of 6 polymeric materials and stainless steel, polymethylmethacrylate microneedles present superiority in all aspects including the reduction of tissue fibrosis, and the expression of α-SMA, Ki-67 protein and TGF-β1 mRNA. On the other hand, polycarbonates, polyurethane, and polylactic-co-glycolic acid microneedles could suppress three biomarker expressions.© 2023 The Author(s).

KW - PRACTICAL GUIDELINES

KW - MANAGEMENT

UR - http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000914801600001

U2 - 10.1039/d2na00604a

DO - 10.1039/d2na00604a

M3 - RGC 21 - Publication in refereed journal

C2 - 36756522

SN - 2516-0230

VL - 5

SP - 927

EP - 933

JO - Nanoscale Advances

JF - Nanoscale Advances

IS - 3

ER -

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

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GRF: Development of Framework Nucleic Acid based platform technology for intradermal and transdermal delivery of oligonucleotides therapeutics

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Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

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Other Files and Links

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GRF: Development of Framework Nucleic Acid based platform technology for intradermal and transdermal delivery of oligonucleotides therapeutics

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