Comparison of the clinical characteristics and mortalities of severe COVID-19 patients between pre- and post-menopause women and age-matched men

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Danyong Liu
  • Han-Lin Ding
  • Yao Chen
  • De-Hong Chen
  • Changming Yang
  • Liu-Ming Yang
  • Liangqing Zhang
  • Zhong-Yuan Xia
  • Xi-He Zhang
  • Shaoqing Lei
  • Zhengyuan Xia

Detail(s)

Original languageEnglish
Pages (from-to)21903-21913
Journal / PublicationAging
Volume13
Issue number18
Online published22 Sep 2021
Publication statusPublished - 30 Sep 2021
Externally publishedYes

Link(s)

Abstract

The mortality rate of young female COVID-19 patients is reported to be lower than that of young males but no significant difference in mortality was found between female and male COVID-19 patients aged over 65 years, and the underlying mechanism is unknown. We retrospectively analyzed clinical characteristics and outcomes of severely ill pre- and post-menopausal COVID-19 patients and compared with age-matched males. Of the 459 patients included, 141 aged ≤55, among whom 19 died (16 males vs. 3 females, p<0.005). While for patients >55 years (n=318), 115 died (47 females vs. 68 males, p=0.149). In patients ≤55 years old, the levels of NLR, median LDH, median c-reactive protein and procalcitonin were significantly higher while the median lymphocyte count and LCR were lower in male than in female (all p<0.0001). In patients over 55, these biochemical parameters were far away from related normal/reference values in the vast majority of these patients in both genders which were in contrast to that seen in the young group. It is concluded that the mortality of severely ill pre-menopausal but not post-menopausal COVID-19 female patients is lower than age-matched male. Our findings support the notion that estrogen plays a beneficial role in combating COVID-19.

Research Area(s)

  • COVID-19, estrogen, menopausal, mortality, severely

Citation Format(s)

Comparison of the clinical characteristics and mortalities of severe COVID-19 patients between pre- and post-menopause women and age-matched men. / Liu, Danyong; Ding, Han-Lin; Chen, Yao; Chen, De-Hong; Yang, Changming; Yang, Liu-Ming; Liu, Jessica Aijia; Zhang, Liangqing; Xia, Zhong-Yuan; Zhang, Xi-He; Lei, Shaoqing; Xia, Zhengyuan.

In: Aging, Vol. 13, No. 18, 30.09.2021, p. 21903-21913.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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