TY - JOUR
T1 - Comparison of characteristics and biocompatibility of green synthesized iron oxide nanoparticles with chemical synthesized nanoparticles
AU - Dowlath, Mohammed Junaid Hussain
AU - Musthafa, Shazia Anjum
AU - Mohamed Khalith, S. B.
AU - Varjani, Sunita
AU - Karuppannan, Sathish Kumar
AU - Ramanujam, Ganesh Munuswamy
AU - Arunachalam, Aarrthy M.
AU - Arunachalam, Kantha Deivi
AU - Chandrasekaran, Murugesan
AU - Chang, Soon Woong
AU - Chung, Woo Jin
AU - Ravindran, Balasubramani
PY - 2021/10
Y1 - 2021/10
N2 - Iron oxide nanoparticles synthesis is an expanding area of research due of their magnetic properties and possible applications in several novel technologies. FeONPs are indispensable in the biomedical field for diagnosis, treatments and drug delivery and in bioremediation applications. The synthesis route of nanoparticles is a major concern because biological methods are eco-friendly, and chemical methods are considered toxic. The objective of this study is to synthesize FeONPs by two different methods and to compare their properties and efficiency in applications. FeONPs were synthesized and characterized by microscopic and various spectroscopic techniques. The synthesized FeONPs were screened for their cytotoxic activity on PBMCs using MTT assay and found to exhibit good biocompatibility. Moreover, the GS FeONPs exhibited potential antibacterial activities and meanwhile showed less toxicity in brine shrimp lethality assay. Hence, these nanoparticles are biocompatible, environmentally safe and can be utilized in many medical applications. © 2021 Elsevier Inc.
AB - Iron oxide nanoparticles synthesis is an expanding area of research due of their magnetic properties and possible applications in several novel technologies. FeONPs are indispensable in the biomedical field for diagnosis, treatments and drug delivery and in bioremediation applications. The synthesis route of nanoparticles is a major concern because biological methods are eco-friendly, and chemical methods are considered toxic. The objective of this study is to synthesize FeONPs by two different methods and to compare their properties and efficiency in applications. FeONPs were synthesized and characterized by microscopic and various spectroscopic techniques. The synthesized FeONPs were screened for their cytotoxic activity on PBMCs using MTT assay and found to exhibit good biocompatibility. Moreover, the GS FeONPs exhibited potential antibacterial activities and meanwhile showed less toxicity in brine shrimp lethality assay. Hence, these nanoparticles are biocompatible, environmentally safe and can be utilized in many medical applications. © 2021 Elsevier Inc.
KW - Brine shrimp assay
KW - Cardiospermum halicacabum
KW - Cytotoxicity
KW - Magnetic materials
KW - Peripheral blood mononuclear cells
KW - ROS scavenging
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85109451704&origin=recordpage
U2 - 10.1016/j.envres.2021.111585
DO - 10.1016/j.envres.2021.111585
M3 - RGC 21 - Publication in refereed journal
C2 - 34181925
SN - 0013-9351
VL - 201
JO - Environmental Research
JF - Environmental Research
M1 - 111585
ER -
