Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

10 Scopus Citations
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Author(s)

  • Long Wu
  • Shuping Lin
  • Ding Li

Detail(s)

Original languageEnglish
Pages (from-to)3355-3358
Journal / PublicationOrganic Letters
Volume10
Issue number15
Publication statusPublished - 2008

Abstract

(Chemical Equation Presented) Enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation were comparatively investigated through mechanistic studies for inactivation of the enzymes with methylenecyclopropylformyl-CoA and 3-octynoyl-CoA. Methylenecyclopropylformyl- CoA can inactivate both enzymes, while 3-octynoyl-CoA inactivates enoyl-CoA hydratase 2 only. The study increased our understanding of these two enzymes in fatty acid oxidation. © 2008 American Chemical Society.