Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation

Long Wu; Shuping Lin; Ding Li

doi:10.1021/ol801267e

Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation

Long Wu, Shuping Lin, Ding Li

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

15 Citations (Scopus)

Abstract

(Chemical Equation Presented) Enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation were comparatively investigated through mechanistic studies for inactivation of the enzymes with methylenecyclopropylformyl-CoA and 3-octynoyl-CoA. Methylenecyclopropylformyl- CoA can inactivate both enzymes, while 3-octynoyl-CoA inactivates enoyl-CoA hydratase 2 only. The study increased our understanding of these two enzymes in fatty acid oxidation. © 2008 American Chemical Society.

Original language	English
Pages (from-to)	3355-3358
Journal	Organic Letters
Volume	10
Issue number	15
DOIs	https://doi.org/10.1021/ol801267e
Publication status	Published - 2008

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title = "Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation",

abstract = "(Chemical Equation Presented) Enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation were comparatively investigated through mechanistic studies for inactivation of the enzymes with methylenecyclopropylformyl-CoA and 3-octynoyl-CoA. Methylenecyclopropylformyl- CoA can inactivate both enzymes, while 3-octynoyl-CoA inactivates enoyl-CoA hydratase 2 only. The study increased our understanding of these two enzymes in fatty acid oxidation. {\textcopyright} 2008 American Chemical Society.",

author = "Long Wu and Shuping Lin and Ding Li",

year = "2008",

doi = "10.1021/ol801267e",

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journal = "Organic Letters",

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T1 - Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation

AU - Wu, Long

AU - Lin, Shuping

AU - Li, Ding

PY - 2008

Y1 - 2008

N2 - (Chemical Equation Presented) Enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation were comparatively investigated through mechanistic studies for inactivation of the enzymes with methylenecyclopropylformyl-CoA and 3-octynoyl-CoA. Methylenecyclopropylformyl- CoA can inactivate both enzymes, while 3-octynoyl-CoA inactivates enoyl-CoA hydratase 2 only. The study increased our understanding of these two enzymes in fatty acid oxidation. © 2008 American Chemical Society.

AB - (Chemical Equation Presented) Enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation were comparatively investigated through mechanistic studies for inactivation of the enzymes with methylenecyclopropylformyl-CoA and 3-octynoyl-CoA. Methylenecyclopropylformyl- CoA can inactivate both enzymes, while 3-octynoyl-CoA inactivates enoyl-CoA hydratase 2 only. The study increased our understanding of these two enzymes in fatty acid oxidation. © 2008 American Chemical Society.

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U2 - 10.1021/ol801267e

DO - 10.1021/ol801267e

M3 - RGC 21 - Publication in refereed journal

C2 - 18611036

SN - 1523-7060

VL - 10

SP - 3355

EP - 3358

JO - Organic Letters

JF - Organic Letters

IS - 15

ER -

Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation

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