Comparative characterization of nontyphoidal Salmonella isolated from humans and food animals in China, 2003–2011

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

5 Scopus Citations
View graph of relations

Author(s)

  • Congming Wu
  • Meiyin Yan
  • Lizhang Liu
  • Jing Lai
  • Edward Wai-chi Chan

Detail(s)

Original languageEnglish
Article numbere00613
Journal / PublicationHeliyon
Volume4
Issue number4
Online published30 Apr 2018
Publication statusPublished - Apr 2018
Externally publishedYes

Abstract

Food animals are major reservoirs from which specific pathogenic Salmonella strains emerge periodically. Probing the identity and origin of such organisms is essential for formulation of highly-focused infection control measures and analysis of factors underlying dissemination of such strains. In this work, the genetic and phenotypic features of animal and human clinical isolates collected at different geographical localities in China during the period 2003–2011 were characterized and compared. Animal-specific serotypes were identified, with S. Enteritidis, S. Cremieu and S. Fyris being recovered almost exclusively from chicken, ducks and pigs respectively. Nevertheless, only four serotypes were commonly found to be transmitted among both animal and human clinical isolates: S. Enteritidis, S. Typhimurium, S. Derby and S. Indiana. Strains of the serotypes S. Enteritidis and S. Typhimurium not only accounted for up to 50% of all human clinical isolates tested, but often shared identical genetic profiles with the animal isolates. Using a recently identified mobile efflux gene, oqxAB, as genetic marker for assessing the efficiency of transmission between animal and human isolates, we demonstrated that a newly emerged genetic trait could be simultaneously detectable among both animal and human clinical isolates. Findings in this work show that transmission of Salmonellae between animal and human is highly efficient and serotype dependent.

Research Area(s)

  • Infectious disease, Microbiology, Veterinary medicine

Citation Format(s)

Comparative characterization of nontyphoidal Salmonella isolated from humans and food animals in China, 2003–2011. / Wu, Congming; Yan, Meiyin; Liu, Lizhang; Lai, Jing; Chan, Edward Wai-chi; Chen, Sheng.

In: Heliyon, Vol. 4, No. 4, e00613, 04.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review