Communication between nitric oxide synthase and positively-charged surface and bone formation promotion

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

11 Scopus Citations
View graph of relations

Author(s)

  • Wei Zhang
  • Jun Liu
  • Haigang Shi
  • Kun Yang
  • Pingli Wang
  • Gexia Wang
  • Na Liu
  • Huaiyu Wang
  • Junhui Ji

Detail(s)

Original languageEnglish
Pages (from-to)354-362
Journal / PublicationColloids and Surfaces B: Biointerfaces
Volume148
Publication statusPublished - 1 Dec 2016

Abstract

Despite the effects on physiology of bone marrow mesenchymal stem cells (BMSCs) and bone tissue, biological signal communication between bone implants and them is seldom employed as a guidance to create an osteo-inductive interface. Herein, the positively-charged surface is constructed on bone implant from the perspective of mediation of nitric oxide synthase (NOS) expression to signal BMSCs osteo-differentiation. In vitro and in vivo results indicate that the proper surface potential on the positively-charged surface affects NOS to express a high level of inducible nitric oxide synthase (iNOS) in three NOS isoforms of the contacted BMSCs, upregulates their osteogenetic expression, and ultimately foster new bone growth. However, an excessively high surface potential produces substantial immunomodulatory effects thereby offsetting the aforementioned advantages. This study demonstrates that fine-tuning of the positively-charged surface and proper utilization of the communication between NOS and bone implants promote bone formation.

Research Area(s)

  • NOS, Orthopedic implant, Osteogenesis, Positively-charged surface, Surface potential

Citation Format(s)

Communication between nitric oxide synthase and positively-charged surface and bone formation promotion. / Zhang, Wei; Liu, Jun; Shi, Haigang; Yang, Kun; Wang, Pingli; Wang, Gexia; Liu, Na; Wang, Huaiyu; Ji, Junhui; Chu, Paul K.

In: Colloids and Surfaces B: Biointerfaces, Vol. 148, 01.12.2016, p. 354-362.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review