Common genetic variants in peroxisome proliferator-activated receptor-γ (PPARG) and type 2 diabetes risk among women's health initiative postmenopausal women

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

13 Scopus Citations
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Author(s)

  • Tianhua Niu
  • Yunsheng Ma
  • Nai-Chieh Y. You
  • Yiqing Song
  • Eric M. Sobel
  • Yi-Hsiang Hsu
  • Raji Balasubramanian
  • Yongxia Qiao
  • Lesley Tinker
  • Simin Liu

Detail(s)

Original languageEnglish
Pages (from-to)E600-E604
Journal / PublicationJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number3
Publication statusPublished - Mar 2013
Externally publishedYes

Abstract

Context: Peroxisome proliferator-activated receptor-γ (PPARG) plays a pivotal role in adipogenesis and glucose homeostasis.
Objective: We investigated whether PPARG gene variants were associated with type 2 diabetes (T2D) risk in the multiethnic Women's Health Initiative (WHI). 
Research Design and Methods: We assessed PPARG single-nucleotide polymorphisms (SNPs) in a case-control study nested in the prospective WHI observational study (WHI-OS) (1543 T2D cases and 2170 matched controls). After identifying 24 tagSNPs, we used multivariable logistic regression models and haplotype-based analyses to estimate these tagSNP-T2D associations. Single-SNP analyses were also conducted in another study of 5642 African American and Hispanic American women in the WHI SNP Health Association Resource (WHI-SHARe). 
Results: We found a borderline significant association between the Pro12Ala (rs1801282) variant and T2D risk in WHI-OS [odds ratio (OR) 0.51, 95% confidence interval (CI) 0.31-0.83, P = .01, combined group, additive model; P = .04, Hispanic American] and WHI-SHARe (OR 0.25, 95% CI 0.08-0.77, P = .02, Hispanic American) participants. In promoter region, rs6809631, rs9817428, rs10510411, rs12629293, and rs12636454 were also associated with T2D risk (range ORs0.68-0.78, 95% CIs 0.52-0.91 to 0.60-1.00, P≤.05)in WHI-OS, in which rs9817428 was replicated in then WHI-SHARe Hispanic American group (P = .04). 
Conclusions: The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. Additional significant loci included 5 PPARG promoter variants. 

Citation Format(s)

Common genetic variants in peroxisome proliferator-activated receptor-γ (PPARG) and type 2 diabetes risk among women's health initiative postmenopausal women. / Chan, Kei Hang K.; Niu, Tianhua; Ma, Yunsheng; You, Nai-Chieh Y.; Song, Yiqing; Sobel, Eric M.; Hsu, Yi-Hsiang; Balasubramanian, Raji; Qiao, Yongxia; Tinker, Lesley; Liu, Simin.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 3, 03.2013, p. E600-E604.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal