Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

11 Scopus Citations
View graph of relations

Author(s)

  • Huihui Chen
  • Kin-Sang Cho
  • T. H. Khanh Vu
  • Ching-Hung Shen
  • Mandeep Kaur
  • Guochun Chen
  • Rose Mathew
  • M. Lisa McHam
  • Ahad Fazelat
  • Kameran Lashkari
  • Joyce Ka Yu Tse
  • Yingqian Li
  • Honghua Yu
  • Lanbo Yang
  • Joan Stein-Streilein
  • Clifford J. Woolf
  • Mark T. Whary
  • Martine J. Jager
  • James G. Fox
  • Jianzhu Chen
  • Dong F. Chen

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number3209
Journal / PublicationNature Communications
Volume9
Issue number1
Early online date10 Aug 2018
Publication statusE-pub ahead of print - 10 Aug 2018

Link(s)

Abstract

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocular pressure (IOP) is sufficient to induce T-cell infiltration into the retina. This T-cell infiltration leads to a prolonged phase of retinal ganglion cell degeneration that persists after IOP returns to a normal level. Heat shock proteins (HSP) are identified as target antigens of T-cell responses in glaucomatous mice and human glaucoma patients. Furthermore, retina-infiltrating T cells cross-react with human and bacterial HSPs; mice raised in the absence of commensal microflora do not develop glaucomatous T-cell responses or the associated neurodegeneration. These results provide compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.

Research Area(s)

Citation Format(s)

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. / Chen, Huihui; Cho, Kin-Sang; Vu, T. H. Khanh; Shen, Ching-Hung; Kaur, Mandeep; Chen, Guochun; Mathew, Rose; McHam, M. Lisa; Fazelat, Ahad; Lashkari, Kameran; Au, Ngan Pan Bennett; Tse, Joyce Ka Yu; Li, Yingqian; Yu, Honghua; Yang, Lanbo; Stein-Streilein, Joan; Ma, Chi Him Eddie; Woolf, Clifford J.; Whary, Mark T.; Jager, Martine J.; Fox, James G.; Chen, Jianzhu; Chen, Dong F.

In: Nature Communications, Vol. 9, No. 1, 3209, 10.08.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

Download Statistics

No data available