Combined optical and mechanical scanning in optical-resolution photoacoustic microscopy

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

1 Scopus Citations
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Author(s)

  • Lei Li
  • Chenghung Yeh
  • Song Hu
  • Brian T. Soetikno
  • Ruimin Chen
  • Qifa Zhou
  • K. Kirk Shung
  • Konstantin I. Maslov
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8943
ISBN (print)9780819498564
Publication statusPublished - 2014
Externally publishedYes

Publication series

Name
Volume8943
ISSN (Print)1605-7422

Conference

TitlePhotons Plus Ultrasound: Imaging and Sensing 2014
PlaceUnited States
CitySan Francisco
Period2 - 5 February 2014

Abstract

Combined optical and mechanical scanning (COMS) in optical-resolution photoacoustic microscopy (OR-PAM) has provided five scanning modes with fast imaging speed and wide field of view (FOV). With two-dimensional (2D) galvanometer-based optical scanning, we have achieved a 2 KHz B-scan rate and 50 Hz volumetric-scan rate, which enables real-time tracking of cell activities in vivo. With optical-mechanical hybrid 2D scanning, we are able to image a wide FOV (10×8 mm2) within 150 seconds, which is 20 times faster than the conventional mechanical scan in our second-generation OR-PAM. With three-dimensional mechanical-based contour scanning, we can maintain the optimal signal-to-noise ratio and spatial resolution of OR-PAM while imaging objects with uneven surfaces, which is ideal for fast and quantitative studies of tumors and the brain. © 2014 SPIE.

Research Area(s)

  • Medical and biological imaging, Photoacoustic imaging, Scanning microscopy, Three-dimensional microscopy

Citation Format(s)

Combined optical and mechanical scanning in optical-resolution photoacoustic microscopy. / Li, Lei; Yeh, Chenghung; Hu, Song et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943 SPIE, 2014. 89435X.

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review