Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Pages (from-to) | 11587-11590 |
Journal / Publication | Chemical Communications |
Volume | 51 |
Issue number | 58 |
Online published | 12 Jun 2015 |
Publication status | Published - 25 Jul 2015 |
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Abstract
A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.
Citation Format(s)
Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. / Wang, Zhigang; Ma, Rong; Yan, Li et al.
In: Chemical Communications, Vol. 51, No. 58, 25.07.2015, p. 11587-11590.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review