Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

Zhigang Wang; Rong Ma; Li Yan; Xianfeng Chen; Guangyu Zhu

doi:10.1039/c5cc04376j

Author(s)

Zhigang Wang
Rong Ma
Li Yan
Xianfeng Chen
Guangyu Zhu

Related Research Unit(s)

Shenzhen Research Institute

Detail(s)

Original language	English
Pages (from-to)	11587-11590
Journal / Publication	Chemical Communications
Volume	51
Issue number	58
Online published	12 Jun 2015
Publication status	Published - 25 Jul 2015

Link(s)

DOI	DOI https://doi.org/10.1039/c5cc04376j Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84936085429&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(c8461c97-63b8-40de-b803-5b9f831e9072).html

Abstract

A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC₅₀ values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.

Citation Format(s)

[ RIS ] [ BibTeX ]

Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. / Wang, Zhigang; Ma, Rong; Yan, Li et al.

In: Chemical Communications, Vol. 51, No. 58, 25.07.2015, p. 11587-11590.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Wang, Z, Ma, R, Yan, L, Chen, X & Zhu, G 2015, 'Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance', Chemical Communications, vol. 51, no. 58, pp. 11587-11590. https://doi.org/10.1039/c5cc04376j

Wang, Z., Ma, R., Yan, L., Chen, X., & Zhu, G. (2015). Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. Chemical Communications, 51(58), 11587-11590. https://doi.org/10.1039/c5cc04376j

Wang Z, Ma R, Yan L, Chen X, Zhu G. Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. Chemical Communications. 2015 Jul 25;51(58):11587-11590. Epub 2015 Jun 12. doi: 10.1039/c5cc04376j

Wang, Zhigang ; Ma, Rong ; Yan, Li et al. / Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. In: Chemical Communications. 2015 ; Vol. 51, No. 58. pp. 11587-11590.