TY - GEN
T1 - COMBINATION OF OPTICAL MANIPULATION OF PARTICLES AND PATTERNING OF HYDROGELS FOR DEMONSTRATION OF DIGITAL DRUG COCKTAILS
AU - Chung, Ko-Chin
AU - Lee, Wen-Bin
AU - Fu, Chien-Yu
AU - Wang, Chih-Hung
AU - Lee, Gwo-Bin
PY - 2017/1
Y1 - 2017/1
N2 - This study presents an integrated microfluidic system combining two techniques, including an optically-induced dielectrophoresis (ODEP) module for manipulation of drug particles and an UV-direct-writing module capable of patterning of hydrogel, for applications of digital drug cocktails. This system was able to provide an automatic and customized production of drug cocktails. Experimental results showed that poly (ethylene glycol) diacrylate (PEGDA) hydrogel performed well under the ODEP operation which made it possible to be manipulated and UV-cured to form the drug particles. Moreover, a drug cocktail could be formed in less than 30∼60 seconds. With a digital micromirror device (DMD) to form an UV-direct-writing module, the UV-curable pattern could be easily designed and formed, thereby allowing the formation of drug cocktails patterned in different shapes.
AB - This study presents an integrated microfluidic system combining two techniques, including an optically-induced dielectrophoresis (ODEP) module for manipulation of drug particles and an UV-direct-writing module capable of patterning of hydrogel, for applications of digital drug cocktails. This system was able to provide an automatic and customized production of drug cocktails. Experimental results showed that poly (ethylene glycol) diacrylate (PEGDA) hydrogel performed well under the ODEP operation which made it possible to be manipulated and UV-cured to form the drug particles. Moreover, a drug cocktail could be formed in less than 30∼60 seconds. With a digital micromirror device (DMD) to form an UV-direct-writing module, the UV-curable pattern could be easily designed and formed, thereby allowing the formation of drug cocktails patterned in different shapes.
UR - http://www.scopus.com/inward/record.url?scp=85015786365&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85015786365&origin=recordpage
U2 - 10.1109/MEMSYS.2017.7863664
DO - 10.1109/MEMSYS.2017.7863664
M3 - RGC 32 - Refereed conference paper (with host publication)
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 1325
EP - 1328
BT - 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)
PB - IEEE
T2 - 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2017)
Y2 - 22 January 2017 through 26 January 2017
ER -