Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019
Related Research Unit(s)
|Number of pages||9|
|Journal / Publication||Emerging Microbes and Infections|
|Online published||29 Jan 2020|
|Publication status||Published - 2020|
Publisher's Copyright Statement
|Link to Scopus||https://www.scopus.com/record/display.uri?eid=2-s2.0-85078691115&origin=recordpage|
To investigate whether introduction of colistin into the clinical settings selected colistin-resistant CRE, we performed molecular epidemiological study of 1868 CRE strains collected from different geographical locales in China during the period 2014–2019. 1755 (96.18%) isolates carried the carbapenemase genes blaKPC and blaNDM; 14 Escherichia coli isolates (0.75%) carrying mcr-1 and blaNDM (MCR-CREC) were also identified. Importantly, the number and relative prevalence of MCR-CREC isolates increased from 5 (0.41%) to 9 (1.38%) after introduction of polymyxin into clinical practice. Consistently, results of genetic analysis indicated that MCR-CREC strains collected before December 2017 were genetically diverse, yet those collected after that date exhibited more closely related genetic profiles, indicating that specific MCR-CREC strains were rapidly selected as a result of increased usage of colistin in clinical settings. The resistance level of MCR-CREC isolates to colistin increased after the introduction of polymyxin into clinical use with the MIC to colistin from <2 mg/L in 80% strains to 2 mg/L in 100% strains. Further dissemination of MCR-CREC strains, which exhibit resistance to the last-line drugs of carbapenems and colistin, is expected to pose a severe threat to human health.
- Carbapenem-resistant Enterobacteriaceae, China, clinical uses, colistin, mcr-1
Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019. / Huang, Hong; Dong, Ning; Shu, Lingbin; Lu, Jiayue; Sun, Qiaoling; Chan, Edward Wai-Chi; Chen, Sheng; Zhang, Rong.In: Emerging Microbes and Infections, Vol. 9, No. 1, 2020, p. 237-245.