Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Ning Dong
  • Lingbin Shu
  • Jiayue Lu
  • Qiaoling Sun
  • Rong Zhang

Detail(s)

Original languageEnglish
Pages (from-to)237-245
Number of pages9
Journal / PublicationEmerging Microbes and Infections
Volume9
Issue number1
Online published29 Jan 2020
Publication statusPublished - 2020

Link(s)

Abstract

To investigate whether introduction of colistin into the clinical settings selected colistin-resistant CRE, we performed molecular epidemiological study of 1868 CRE strains collected from different geographical locales in China during the period 2014–2019. 1755 (96.18%) isolates carried the carbapenemase genes blaKPC and blaNDM; 14 Escherichia coli isolates (0.75%) carrying mcr-1 and blaNDM (MCR-CREC) were also identified. Importantly, the number and relative prevalence of MCR-CREC isolates increased from 5 (0.41%) to 9 (1.38%) after introduction of polymyxin into clinical practice. Consistently, results of genetic analysis indicated that MCR-CREC strains collected before December 2017 were genetically diverse, yet those collected after that date exhibited more closely related genetic profiles, indicating that specific MCR-CREC strains were rapidly selected as a result of increased usage of colistin in clinical settings. The resistance level of MCR-CREC isolates to colistin increased after the introduction of polymyxin into clinical use with the MIC to colistin from <2 mg/L in 80% strains to 2 mg/L in 100% strains. Further dissemination of MCR-CREC strains, which exhibit resistance to the last-line drugs of carbapenems and colistin, is expected to pose a severe threat to human health.

Research Area(s)

  • Carbapenem-resistant Enterobacteriaceae, China, clinical uses, colistin, mcr-1

Citation Format(s)

Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019. / Huang, Hong; Dong, Ning; Shu, Lingbin; Lu, Jiayue; Sun, Qiaoling; Chan, Edward Wai-Chi; Chen, Sheng; Zhang, Rong.

In: Emerging Microbes and Infections, Vol. 9, No. 1, 2020, p. 237-245.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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