Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
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Author(s)

  • Keming Xu
  • Liang Li
  • Mingyue Cui
  • Yiyuan Han
  • H. Enis Karahan
  • Vincent T. K. Chow

Detail(s)

Original languageEnglish
Pages (from-to)18440-18449
Journal / PublicationACS Applied Materials and Interfaces
Volume9
Issue number22
Online published17 May 2017
Publication statusPublished - 7 Jun 2017
Externally publishedYes

Abstract

Pneumonia is the major cause of death in children under five, particularly in developing countries. Antibiotics such as amoxicillin greatly help in mitigating this problem. However, there is a lack of an infant/toddler-friendly formulation for countries with limited clean water orr electricity. Here, we report the development of a shear-thinning hydrogel system for the oral delivery of amoxicillin to infant/toddler patients, without the need of clean water and refrigeration. The hydrogel formulation consists of metolose (hydroxypropyl methylcellulose) and amoxicillin. It preserves the structural integrity of antibiotics and their antibacterial activity over 12 weeks at room temperature. Pharmacokinetic profiling of mice reveals that the hydrogel formulation increases the bioavailability of drugs by ∼18% compared to that with aqueous amoxicillin formulation. More importantly, oral gavage of this formulation in a mouse model of secondary pneumococcal pneumonia significantly ameliorates inflammatory infiltration and tissue damage in lungs, with a 10-fold reduction in bacterial counts compared to those in untreated ones. Given the remarkable antibacterial efficacy as well as the use of FDA-regulated ingredients (metolose and amoxicillin), the hydrogel formulation holds great promise for rapid clinical translation.

Research Area(s)

  • amoxicillin, metolose, pediatric formulation, pneumonia, shear-thinning hydrogel

Citation Format(s)

Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia. / Xu, Keming; Li, Liang; Cui, Mingyue; Han, Yiyuan; Karahan, H. Enis; Chow, Vincent T. K.; Xu, Chenjie.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 22, 07.06.2017, p. 18440-18449.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review