Cognitive reserve modulates the neurophysiological complexity of the aging brain
Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Publication status | Published - Nov 2021 |
Conference
Title | 50th Annual Meeting Society for Neuroscience |
---|---|
Location | McCormick Place Convention Center |
Place | United States |
City | Illinois |
Period | 13 - 16 November 2021 |
Link(s)
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(6f06fc34-e80a-4d9e-a188-0da4b54e871c).html |
---|
Abstract
Normal aging experiences a general decrement in physiological function and cognitive abilities, and
the age-related neurocognitive declines is highly variable within the aged population. Previous studies
have suggested that Cognitive Reserve (CR) factor such as education could cope with the
neurocognitive impairments emerging as a consequence of age-associated brain damage or
pathology. Given that age-related and individual differences in neurocognitive function are associated
with dynamic processes of the functional brain networks, we hypothesized that CR may involve
facilitating age-related changes in flexibility and efficiency of neural networks and individual variations
in educational level would be associated with altered functional brain complexity of the aging brain. In this resting-state functional magnetic resonance imaging (rs-fMRI) study, we applied multiscale
entropy, cross-sample entropy, and neuropsychological approaches to examine whether and how
educational level impacts the complexity of brain function, intrinsic networks, and cognitive ability in
healthy aging. The rs-fMRI results showed that, compared with the healthy elder with lower CR, the
healthy elder with higher CR presented better performance of executive function, youthful brain
entropy and increased efficiency of networks in fronto-parietal (FPN), cingulo-opercular (CON), and
default mode network (DMN). These findings provide neurobiological evidence of CR and suggest that
CR may facilitate and scaffold neural networks of the aging brain to act as a protective mechanism.
Citation Format(s)
Cognitive reserve modulates the neurophysiological complexity of the aging brain. / Huang, C.-M.; Su, Y.-C.; Lin, C. et al.
2021. Paper presented at 50th Annual Meeting Society for Neuroscience , Illinois, United States.
2021. Paper presented at 50th Annual Meeting Society for Neuroscience , Illinois, United States.
Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review