Coexistence of Antibiotic Resistance Genes and Virulence Factors Deciphered by Large-Scale Complete Genome Analysis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Yu Pan
  • Jiaxiong Zeng
  • Liguan Li
  • Jintao Yang
  • Ziyun Tang
  • Wenguang Xiong
  • Yafei Li
  • Zhenling Zeng

Detail(s)

Original languageEnglish
Article numbere00821-19
Journal / PublicationMSYSTEMS
Volume5
Issue number3
Publication statusPublished - May 2020

Link(s)

Abstract

Widespread use of antibiotics has enhanced the evolution of highly resilient pathogens and poses a severe risk to human health via coselection of antibiotic resistance genes (ARGs) and virulence factors (VFs). In this study, we rigorously evaluate the abundance relationship and physical linkage between ARGs and VFs by performing a comprehensive analysis of 9,070 bacterial genomes isolated from multiple species and hosts. The coexistence of ARGs and VFs was observed in bacteria across distinct phyla, pathogenicities, and habitats, especially among human-associated pathogens. The coexistence patterns of gene elements in different habitats and pathogenicity groups were similar, presumably due to frequent gene transfer. A shorter intergenic distance between mobile genetic elements and ARGs/VFs was detected in human/animal-associated bacteria, indicating a higher transfer potential. Increased accumulation of exogenous ARGs/VFs in human pathogens highlights the importance of gene acquisition in the evolution of human commensal bacteria. Overall, the findings provide insights into the genic features of combinations of ARG-VF and expand our understanding of ARG-VF coexistence in bacteria.

Research Area(s)

  • antibiotic resistance, virulence factors, gene coexistence, bacterial genome, pathogens, natural environment, public health risk

Citation Format(s)

Coexistence of Antibiotic Resistance Genes and Virulence Factors Deciphered by Large-Scale Complete Genome Analysis. / Pan, Yu; Zeng, Jiaxiong; Li, Liguan; Yang, Jintao; Tang, Ziyun; Xiong, Wenguang; Li, Yafei; Chen, Sheng; Zeng, Zhenling.

In: MSYSTEMS, Vol. 5, No. 3, e00821-19, 05.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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