Cocooning Wound for Healing

Kaisong Huang; Renjie Tan; Hanbai Wu; Yifan Si; Leqi Lei; Hanyue Lan; Chi-wai Kan; Wenjie Fang; Shuai Zhang; Ke Zhang; Jinlian Hu

doi:10.1021/acs.nanolett.5c00575

Cocooning Wound for Healing

Kaisong Huang (Co-first Author), Renjie Tan (Co-first Author), Hanbai Wu (Co-first Author), Yifan Si, Leqi Lei, Hanyue Lan, Chi-wai Kan, Wenjie Fang, Shuai Zhang, Ke Zhang, Jinlian Hu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Abstract

Wound healing is highly sensitive to environmental conditions. Under solar radiation, elevated wound temperatures and UV-rays can induce oxidative stress, disrupt the wound environment, provoke inflammation, and even cause thermal injury. Lower wound temperatures may hinder angiogenesis and immune function, thus delaying recovery. Inspired by silkworm cocooning for thermal comfort during metamorphosis, we developed the wound cocoon (W-cocoon) using a portable high-speed electro-blow spinning (EBS) device. The W-cocoon integrates radiative cooling and thermal insulation properties, providing both cooling (3.9 °C) under sunlight and warming (1.9 °C) indoors. Based on animal studies, the W-cocoon promotes wound recovery in indoor scenarios, while under solar radiation, its high reflectivity and UV-blocking ratio mitigate the negative effects of radiation, thus optimizing wound healing. Additionally, the W-cocoon exhibits superhydrophobic and hemophobic properties, which endow the dressing with antifouling capabilities and reduce pain during dressing changes. © 2025 American Chemical Society.

Original language	English
Journal	Nano Letters
Online published	21 Mar 2025
DOIs	https://doi.org/10.1021/acs.nanolett.5c00575
Publication status	Online published - 21 Mar 2025

Funding

The authors are thankful for the useful discussions with Dr. Shi Shuo (Hong Kong Polytechnic University) and Mr. Hu Xin(Hong Kong Polytechnic University). The authors also gratefully acknowledge the financial support from the Contract Research (“Development of Breathable Fabrics with Nano-Electrospun Membrane”, CityU ref.: 9231419; “Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”, CityU ref:PJ9240111), the National Natural Science Foundation of China (“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”, Grant No. 51673162), and Startup Grant of CityU (“Laboratory of Wearable Materials for Healthcare”, Grant No. 9380116).

Research Keywords

Passive cooling
Portable device
Superhydrophobic
Thermal comfort
Wound healing

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title = "Cocooning Wound for Healing",

abstract = "Wound healing is highly sensitive to environmental conditions. Under solar radiation, elevated wound temperatures and UV-rays can induce oxidative stress, disrupt the wound environment, provoke inflammation, and even cause thermal injury. Lower wound temperatures may hinder angiogenesis and immune function, thus delaying recovery. Inspired by silkworm cocooning for thermal comfort during metamorphosis, we developed the wound cocoon (W-cocoon) using a portable high-speed electro-blow spinning (EBS) device. The W-cocoon integrates radiative cooling and thermal insulation properties, providing both cooling (3.9 °C) under sunlight and warming (1.9 °C) indoors. Based on animal studies, the W-cocoon promotes wound recovery in indoor scenarios, while under solar radiation, its high reflectivity and UV-blocking ratio mitigate the negative effects of radiation, thus optimizing wound healing. Additionally, the W-cocoon exhibits superhydrophobic and hemophobic properties, which endow the dressing with antifouling capabilities and reduce pain during dressing changes. {\textcopyright} 2025 American Chemical Society.",

keywords = "Passive cooling, Portable device, Superhydrophobic, Thermal comfort, Wound healing",

author = "Kaisong Huang and Renjie Tan and Hanbai Wu and Yifan Si and Leqi Lei and Hanyue Lan and Chi-wai Kan and Wenjie Fang and Shuai Zhang and Ke Zhang and Jinlian Hu",

year = "2025",

month = mar,

day = "21",

doi = "10.1021/acs.nanolett.5c00575",

language = "English",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Cocooning Wound for Healing

AU - Huang, Kaisong

AU - Tan, Renjie

AU - Wu, Hanbai

AU - Si, Yifan

AU - Lei, Leqi

AU - Lan, Hanyue

AU - Kan, Chi-wai

AU - Fang, Wenjie

AU - Zhang, Shuai

AU - Zhang, Ke

AU - Hu, Jinlian

PY - 2025/3/21

Y1 - 2025/3/21

N2 - Wound healing is highly sensitive to environmental conditions. Under solar radiation, elevated wound temperatures and UV-rays can induce oxidative stress, disrupt the wound environment, provoke inflammation, and even cause thermal injury. Lower wound temperatures may hinder angiogenesis and immune function, thus delaying recovery. Inspired by silkworm cocooning for thermal comfort during metamorphosis, we developed the wound cocoon (W-cocoon) using a portable high-speed electro-blow spinning (EBS) device. The W-cocoon integrates radiative cooling and thermal insulation properties, providing both cooling (3.9 °C) under sunlight and warming (1.9 °C) indoors. Based on animal studies, the W-cocoon promotes wound recovery in indoor scenarios, while under solar radiation, its high reflectivity and UV-blocking ratio mitigate the negative effects of radiation, thus optimizing wound healing. Additionally, the W-cocoon exhibits superhydrophobic and hemophobic properties, which endow the dressing with antifouling capabilities and reduce pain during dressing changes. © 2025 American Chemical Society.

AB - Wound healing is highly sensitive to environmental conditions. Under solar radiation, elevated wound temperatures and UV-rays can induce oxidative stress, disrupt the wound environment, provoke inflammation, and even cause thermal injury. Lower wound temperatures may hinder angiogenesis and immune function, thus delaying recovery. Inspired by silkworm cocooning for thermal comfort during metamorphosis, we developed the wound cocoon (W-cocoon) using a portable high-speed electro-blow spinning (EBS) device. The W-cocoon integrates radiative cooling and thermal insulation properties, providing both cooling (3.9 °C) under sunlight and warming (1.9 °C) indoors. Based on animal studies, the W-cocoon promotes wound recovery in indoor scenarios, while under solar radiation, its high reflectivity and UV-blocking ratio mitigate the negative effects of radiation, thus optimizing wound healing. Additionally, the W-cocoon exhibits superhydrophobic and hemophobic properties, which endow the dressing with antifouling capabilities and reduce pain during dressing changes. © 2025 American Chemical Society.

KW - Passive cooling

KW - Portable device

KW - Superhydrophobic

KW - Thermal comfort

KW - Wound healing

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U2 - 10.1021/acs.nanolett.5c00575

DO - 10.1021/acs.nanolett.5c00575

M3 - RGC 21 - Publication in refereed journal

SN - 1530-6984

JO - Nano Letters

JF - Nano Letters

ER -

Cocooning Wound for Healing

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MainGov: 兒童燒傷創面抗菌促修復納米纖維智能敷料的研究與應用

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Cocooning Wound for Healing

Abstract

Funding

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MainGov: 兒童燒傷創面抗菌促修復納米纖維智能敷料的研究與應用

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