Coassembled Nitric Oxide-Releasing Nanoparticles with Potent Antimicrobial Efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA) Strains

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yiyi Liu
  • Xiaoyu Chen
  • Xiangfeng Lai
  • Christian K. O. Dzuvor
  • Letian Lyu
  • Seong Hoong Chow
  • Lizhong He
  • Lei Yu
  • Yajun Wang
  • Jiangning Song
  • Tsung-Wu Lin
  • Philip Wai Hong Chan
  • Hsin-Hui Shen

Detail(s)

Original languageEnglish
Pages (from-to)37369-37379
Journal / PublicationACS Applied Materials and Interfaces
Volume14
Issue number33
Online published11 Aug 2022
Publication statusPublished - 24 Aug 2022

Abstract

Nitric oxide (NO)-releasing nanoparticles are effective nanomedicines with diverse therapeutic advantages compared with small molecule-based NO donors. Here, we report a new class of furoxan-based NO-releasing nanoparticles using a simple, creative yet facile coassembly approach. This is the first time we demonstrated that the coassembled NO-releasing nanoparticles with poly(ethylene glycol)101-block-poly(propylene glycol)56-block-poly(ethylene glycol)101(Pluronic F127) had potent antimicrobial efficacies against methicillin-resistant Staphylococcus aureus (MRSA) strains. Nanoparticles obtained from the coassembly of either 4-(1-(3-methylpentan-5-ol)oxyl)(3-phenylsulfonyl) furoxan (compound 1) or 4-methoxy(3-phenylsulfonyl) furoxan (compound 2) with Pluronic F127 exhibit 4-fold improved antimicrobial activities compared to their self-assembled counterparts without Pluronic F127. 5(6)-Carboxylfluorescein (CF) leakage experiments further reveal that both coassembled NO-releasing nanoparticles show stronger interactions with lipid bilayers than those self-assembled alone. Subsequently, their strong plasma membrane-damaging capabilities are confirmed under both high-resolution optical microscopy and scanning electron microscopy characterizations. This coassembly approach could be readily applied to other small molecule-based antimicrobials, providing new solutions and important insights to further antimicrobial recipe design.

Research Area(s)

  • coassembly, self-assembly, NO releasing, antimicrobial, nanoparticles, NO

Citation Format(s)

Coassembled Nitric Oxide-Releasing Nanoparticles with Potent Antimicrobial Efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA) Strains. / Liu, Yiyi; Chen, Xiaoyu; Lai, Xiangfeng et al.
In: ACS Applied Materials and Interfaces, Vol. 14, No. 33, 24.08.2022, p. 37369-37379.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review