Projects per year
Abstract
Single-atom catalysts have attracted attention in the past decade since they maximize the utilization of active sites and facilitate the understanding of product distribution in some catalytic reactions. Recently, this idea has been extended to single-atom nanozymes (SAzymes) for the mimicking of natural enzymes such as horseradish peroxidase (HRP) often used in bioanalytical applications. Herein, it is demonstrated that those SAzymes without constructing the reaction pocket of HRP still undergo the OH radical-mediated pathway like most of the reported nanozymes. Their positively charged single-atom centers resulting from support electronegative oxygen/nitrogen hinder the reductive conversion of H2O2 to OH radicals and hence display low activity per site. In contrast, it is found that this step can be facilitated over their metallic counterparts on cluster nanozymes with much higher site activity and atom efficiency (cf. SAzymes with 100% atom utilization). Besides the mimicking of HRP in glucose detection, cluster nanozymes are also demonstrated as a better oxidase mimetic for glutathione detection.
Original language | English |
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Article number | 2104844 |
Journal | Small |
Volume | 18 |
Issue number | 5 |
Online published | 25 Nov 2021 |
DOIs | |
Publication status | Published - 3 Feb 2022 |
Research Keywords
- active site reactivity
- atom utilization
- cluster nanozymes
- peroxidase/oxidase mimicking
- single-atom nanozymes
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GRF: The Rational Design of Artificial Nanozymes for Urease Mimicking: the Stoichiometric Release of NH3 from Urea Hydrolysis at Ambient and Elevated Temperature
PENG, Y.-K. (Principal Investigator / Project Coordinator)
1/01/22 → …
Project: Research
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DON_RMG: In-situ Water Removal for Non-reductive CO2 Conversion with Alcohols/Amines into High Value-added Carbonates/Ureas/Carbamates over MgO Nanosheets with Polar (111) Surface - RMGS
PENG, Y.-K. (Principal Investigator / Project Coordinator)
1/03/21 → 7/03/24
Project: Research
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GRF: Bridging the Gap between Natural Enzyme and Artificial Nanozyme: A Thorough Structure-Activity Study of Well-Defined Single Atom Catalysts in Glucose Detection
PENG, Y.-K. (Principal Investigator / Project Coordinator)
1/01/21 → 29/05/25
Project: Research