Clonal emergence of extended-spectrum β-lactamase (CTX-M-2)-producing Salmonella enterica serovar virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003)

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Sophie Bertrand
  • François-Xavier Weill
  • Axel Cloeckaert
  • Martine Vrints
  • Eric Mairiaux
  • Karine Fraud
  • Katlijne Dierick
  • Christa Wildemauve
  • Claudine Godard
  • Hein Imberechts
  • Patrick A. D. Grimont
  • Jean-Marc Collard

Detail(s)

Original languageEnglish
Pages (from-to)2897-2903
Journal / PublicationJournal of Clinical Microbiology
Volume44
Issue number8
Publication statusPublished - Aug 2006
Externally publishedYes

Abstract

Antibiotic treatment is not required in cases of Salmonella enterica gastroenteritis but is essential in cases of enteric fever or invasive salmonellosis or in immunocompromised patients. Although fluoroquinolones and extended-spectrum cephalosporias are the drugs of choice to treat invasive Salmonella, resistance to these antibiotics is increasing worldwide. During the period 2000 to 2003, 90 Salmonella enterica serovar Virchow poultry and poultry product isolates and 11 serovar Virchow human isolates were found to produce an extended-spectrum β-iactamase, CTX-M-2, concomitantly with a TEM-1 β-lactamase. The blaCTX-M-2 gene was located on a large conjugative plasmid (> 100 kb). Pulsed-field gel electrophoresis indicated a clonal relationship between the poultry and human isolates. All these isolates displayed additional resistance to trimethoprim-sulfamethoxazole and tetracycline as well as a reduced susceptibility to ciprofloxacin (MICs of between 0.5 and 1 μg/ml). CTX-M-2-producing Salmonella with a reduced susceptibility to fluoroquinolones constitutes a major concern, since such strains could disseminate on a large scale and jeopardize classical antibiotic therapy in immunocompromised patients. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

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Citation Format(s)

Clonal emergence of extended-spectrum β-lactamase (CTX-M-2)-producing Salmonella enterica serovar virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003). / Bertrand, Sophie; Weill, François-Xavier; Cloeckaert, Axel et al.
In: Journal of Clinical Microbiology, Vol. 44, No. 8, 08.2006, p. 2897-2903.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review