Clinical pilot study: Efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients

Robyn Nagel; Helle Bielefeldt-Ohmann; Rebecca Traub

doi:10.1186/s13099-014-0034-0

Clinical pilot study: Efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients

Robyn Nagel^*
, Helle Bielefeldt-Ohmann
, Rebecca Traub

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

21 Citations (Scopus)

5 Downloads (CityUHK Scholars)

Abstract

Background: Blastocystis species are common human enteric parasites. Carriage has been linked to Irritable Bowel Syndrome (IBS). Treatment of Blastocystis spp. with antimicrobials is problematic and insensitive diagnostic methods and re-infection complicate assessment of eradication. We investigated whether triple antibiotic therapy comprising diloxanide furoate, trimethoprim/sulfamethoxazole and secnidazole (TAB) given to diarrhoea-predominant IBS (D-IBS) patients positive for Blastocystis would achieve eradication. © 2014 Nagel et al.; licensee BioMed Central Ltd.

Original language	English
Article number	34
Journal	Gut Pathogens
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/s13099-014-0034-0
Publication status	Published - 20 Aug 2014
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Blastocystis
Irritable bowel syndrome
PCR
Therapy

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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abstract = "Background: Blastocystis species are common human enteric parasites. Carriage has been linked to Irritable Bowel Syndrome (IBS). Treatment of Blastocystis spp. with antimicrobials is problematic and insensitive diagnostic methods and re-infection complicate assessment of eradication. We investigated whether triple antibiotic therapy comprising diloxanide furoate, trimethoprim/sulfamethoxazole and secnidazole (TAB) given to diarrhoea-predominant IBS (D-IBS) patients positive for Blastocystis would achieve eradication. {\textcopyright} 2014 Nagel et al.; licensee BioMed Central Ltd.",

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AU - Traub, Rebecca

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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Clinical pilot study: Efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients

Abstract

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Research Keywords

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